Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 5/20 | 0.41 |
| ▸ | PTGES | O14684 | 3/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.38 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.38 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.38 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.37 |
| ▸ | CA12 | O43570 | 2/20 | 0.36 |
| ▸ | CA1 | P00915 | 2/20 | 0.36 |
| ▸ | CA2 | P00918 | 2/20 | 0.36 |
| ▸ | CA4 | P22748 | 2/20 | 0.36 |
| ▸ | CA9 | Q16790 | 2/20 | 0.36 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | RORC | P51449 | 1/20 | 0.36 |
| ▸ | OXTR | P30559 | 1/20 | 0.36 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.36 |
| ▸ | PTPN22 | Q9Y2R2 | 2/20 | 0.36 |
| ▸ | BCL2L1 | Q07817 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4762525 | 0.89 | CA1 (0.36) | KEAP1NFE2L2NR3C1CA12CA1 | |
| SCHEMBL4762138 | 0.88 | MCL1 (0.45) | MCL1PTGESALOX5KEAP1NFE2L2 | |
| SCHEMBL5156271 | 0.87 | CA1 (0.43) | MCL1PTGESALOX5KEAP1NFE2L2 | |
| SCHEMBL4659730 | 0.83 | MCL1 (0.37) | MCL1PTGESALOX5NR3C1TRPM8 | |
| SCHEMBL3944734 | 0.82 | BRD4 (0.50) | NR3C1CA1CA2 | |
| SCHEMBL4760593 | 0.82 | BRD4 (0.44) | CA12CA1CA2CA4CA9 | |
| SCHEMBL4762136 | 0.80 | MCL1 (0.49) | MCL1PTGESALOX5KEAP1NFE2L2 | |
| SCHEMBL5155038 | 0.79 | CA1 (0.42) | KEAP1NFE2L2CA12CA1CA2 | |
| SCHEMBL5152108 | 0.78 | CA1 (0.43) | MCL1PTGESALOX5KEAP1NFE2L2 | |
| SCHEMBL4659506 | 0.77 | PTGDR2 (0.37) | KEAP1NFE2L2CA12CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2001847-A2 | SOLUBLE ADENYLATE CYCLASE INHIBITORS | Bayer Schering Pharma AG (DE) | 2008-12-17 | — | — | EP | claimed |
| WO-2007107385-A2 | SOLUBLE ADENYLATE CYCLASE INHIBITORS | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2007-09-27 | — | — | WO | claimed |
| EP-2001847-A2 | SOLUBLE ADENYLATE CYCLASE INHIBITORS | Bayer Schering Pharma AG (DE) | 2008-12-17 | — | — | EP | disclosed |
| WO-2007107385-A2 | SOLUBLE ADENYLATE CYCLASE INHIBITORS | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2007-09-27 | — | — | WO | disclosed |