Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | EDNRA | P25101 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.41 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.41 |
| ▸ | EDNRB | P24530 | 1/20 | 0.41 |
| ▸ | PTPN2 | P17706 | 2/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.41 |
| ▸ | PTPN5 | P54829 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4836640 | 0.86 | EDNRA (0.46) | SLC40A1MEN1KMT2ALMNAMAPT | |
| SCHEMBL4781223 | 0.76 | EDNRB (0.48) | SLC40A1MEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL4781870 | 0.74 | PIK3CG (0.40) | MEN1KMT2ALMNASMN1; SMN2EDNRA | |
| SCHEMBL4780564 | 0.74 | AXL (0.47) | SLC40A1MEN1KMT2ALMNAMAPT | |
| SCHEMBL30304724 | 0.74 | AXL (0.47) | SLC40A1MEN1KMT2ALMNAMAPT | |
| SCHEMBL4842459 | 0.70 | ALDH1A1 (0.47) | SLC40A1MEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL4777395 | 0.70 | AXL (0.54) | SLC40A1MEN1KMT2ALMNATSHR | |
| SCHEMBL16501001 | 0.69 | AXL (0.47) | SLC40A1MEN1KMT2A | |
| SCHEMBL4781581 | 0.68 | AXL (0.49) | SLC40A1MEN1KMT2ALMNATSHR | |
| SCHEMBL4780300 | 0.68 | ALDH1A1 (0.51) | MEN1KMT2ALMNAMAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008008374-A2 | CCR2 INHIBITORS AND METHODS OF USE THEREOF | CHEMOCENTRYX, INC. (US) | 2008-01-17 | — | — | WO | claimed |