Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CG | P48736 | 5/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.40 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.40 |
| ▸ | MTOR | P42345 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | EDNRA | P25101 | 2/20 | 0.39 |
| ▸ | KRAS | P01116 | 1/20 | 0.39 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.39 |
| ▸ | EDNRB | P24530 | 1/20 | 0.38 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.38 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4836640 | 0.88 | EDNRA (0.46) | PIK3CGPIK3CDPIK3CBMTORMEN1 | |
| SCHEMBL4727594 | 0.86 | PIK3CG (0.41) | PIK3CGPIK3CDPIK3CBMTOREDNRA | |
| SCHEMBL4781223 | 0.86 | EDNRB (0.48) | MEN1KMT2AEDNRASCN9AEDNRB | |
| SCHEMBL4780564 | 0.83 | AXL (0.47) | MEN1KMT2ASCN9ALMNASMN1; SMN2 | |
| SCHEMBL30304724 | 0.83 | AXL (0.47) | MEN1KMT2ASCN9ALMNASMN1; SMN2 | |
| SCHEMBL4780300 | 0.78 | ALDH1A1 (0.51) | PIK3CGPIK3CDMEN1KMT2AEDNRA | |
| SCHEMBL4793152 | 0.74 | SLC40A1 (0.46) | MEN1KMT2AEDNRAEDNRBKEAP1 | |
| SCHEMBL4777477 | 0.71 | EDNRB (0.50) | PIK3CGPIK3CDPIK3CBMTOREDNRA | |
| SCHEMBL4846633 | 0.71 | SLC20A2 (0.49) | MEN1KMT2AKEAP1NFE2L2LMNA | |
| SCHEMBL4775594 | 0.71 | SLC20A2 (0.51) | MEN1KMT2AKEAP1NFE2L2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008008374-A2 | CCR2 INHIBITORS AND METHODS OF USE THEREOF | CHEMOCENTRYX, INC. (US) | 2008-01-17 | — | — | WO | claimed |
| WO-2008008374-A2 | CCR2 INHIBITORS AND METHODS OF USE THEREOF | CHEMOCENTRYX, INC. (US) | 2008-01-17 | — | — | WO | disclosed |