Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | EDNRB | P24530 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.45 |
| ▸ | RELA | Q04206 | 1/20 | 0.45 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.42 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4781223 | 0.90 | EDNRB (0.48) | EDNRAMEN1KMT2AALDH1A1EDNRB | |
| SCHEMBL4781870 | 0.88 | PIK3CG (0.40) | EDNRAMEN1KMT2ASMN1; SMN2EDNRB | |
| SCHEMBL30304724 | 0.87 | AXL (0.47) | MEN1KMT2AALDH1A1SMN1; SMN2HSD17B10 | |
| SCHEMBL4780564 | 0.87 | AXL (0.47) | MEN1KMT2AALDH1A1SMN1; SMN2HSD17B10 | |
| SCHEMBL4793152 | 0.86 | SLC40A1 (0.46) | EDNRAMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL4780300 | 0.82 | ALDH1A1 (0.51) | EDNRAMEN1KMT2AALDH1A1TP53 | |
| SCHEMBL4777477 | 0.74 | EDNRB (0.50) | EDNRAEDNRBTP53SLC40A1MAPT | |
| SCHEMBL4846633 | 0.74 | SLC20A2 (0.49) | MEN1KMT2ASLC40A1LMNAKEAP1 | |
| SCHEMBL4775594 | 0.74 | SLC20A2 (0.51) | MEN1KMT2ASLC40A1LMNAKEAP1 | |
| SCHEMBL4727594 | 0.73 | PIK3CG (0.41) | EDNRAALDH1A1HSD17B10PIK3CDPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008008374-A2 | CCR2 INHIBITORS AND METHODS OF USE THEREOF | CHEMOCENTRYX, INC. (US) | 2008-01-17 | — | — | WO | disclosed |