Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 6/20 | 0.43 |
| ▸ | CHUK | O15111 | 6/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | HRH1 | P35367 | 1/20 | 0.36 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4791770 | 0.92 | ADRA2A (0.39) | IKBKBCHUKADRA2AADRA2BADRA2C | |
| SCHEMBL4793423 | 0.86 | PIK3CA (0.43) | ADRA2AADRA2BADRA2CHTTNPSR1 | |
| SCHEMBL4793613 | 0.82 | ITGB3 (0.38) | IKBKBCHUKADRA2AADRA2BADRA2C | |
| SCHEMBL4796331 | 0.76 | ADRA2A (0.37) | IKBKBCHUKADRA2AADRA2BADRA2C | |
| SCHEMBL4792540 | 0.76 | ADRA2A (0.43) | ADRA2AADRA2BADRA2CPTGIRAOC3 | |
| SCHEMBL4792493 | 0.74 | PTH1R (0.42) | ADRA2AADRA2BADRA2CPTGIRAOC3 | |
| SCHEMBL4794483 | 0.74 | PTH1R (0.44) | ADRA2AADRA2BADRA2CPTGIRAOC3 | |
| SCHEMBL4792633 | 0.74 | PTH1R (0.44) | ADRA2AADRA2BADRA2CPTGIRAOC3 | |
| SCHEMBL4795789 | 0.72 | ADRA2A (0.39) | ADRA2AADRA2BADRA2CPTGIRAOC3 | |
| SCHEMBL4906720 | 0.72 | ADRA2A (0.41) | ADRA2AADRA2BADRA2CPTGIRAOC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008009963-A2 | PYRIMIDINE DERIVATIVES AS MODULATORS OF PARATHYROID HORMONE RECEPTORS | JAMES BLACK FOUNDATION LIMITED (GB) | 2008-01-24 | — | — | WO | disclosed |