Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.43 |
| ▸ | APAF1 | O14727 | 2/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 4/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | MMP13 | P45452 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | CASP7 | P55210 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4781385 | 0.88 | MAPT (0.43) | MAPTKDM4EAPAF1RECQLGAA | |
| SCHEMBL4782089 | 0.87 | KDM4E (0.51) | MAPTKDM4EAPAF1RECQLGAA | |
| SCHEMBL4782136 | 0.86 | MAPT (0.45) | MAPTKDM4EAPAF1RECQLGAA | |
| SCHEMBL4780159 | 0.82 | KDM4E (0.45) | MAPTKDM4EAPAF1RECQLGAA | |
| SCHEMBL4781252 | 0.80 | KDM4E (0.52) | MAPTKDM4EAPAF1RECQLGAA | |
| SCHEMBL4782085 | 0.79 | BCAT1 (0.49) | MAPTKDM4EGAAAURKAKDR | |
| SCHEMBL4796043 | 0.78 | ALDH1A1 (0.51) | MAPTKDM4EAPAF1RECQLAURKA | |
| SCHEMBL4796798 | 0.78 | EGFR (0.47) | MAPTKDM4EAPAF1RECQLGAA | |
| SCHEMBL4782567 | 0.78 | IGF1R (0.48) | MAPTKDM4EAPAF1RECQLGAA | |
| SCHEMBL4782147 | 0.73 | IGF1R (0.49) | MAPTKDM4EAPAF1RECQLGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008025526-A1 | INDOLE DERIVATIVES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-03-06 | — | — | WO | claimed |
| WO-2008025526-A1 | INDOLE DERIVATIVES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-03-06 | — | — | WO | disclosed |