Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CG | P48736 | 5/20 | 0.48 |
| ▸ | GPR27 | Q9NS67 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | SLC40A1 | Q9NP59 | 2/20 | 0.43 |
| ▸ | CCR2 | P41597 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | CCR4 | P51679 | 1/20 | 0.41 |
| ▸ | CCR5 | P51681 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | CCR9 | P51686 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1762607 | 0.90 | CCR9 (0.48) | CCR2ALDH1A1KDM4ECCR9 | |
| SCHEMBL305792 | 0.79 | CCR9 (0.48) | PIK3CGPIK3CDCCR9 | |
| SCHEMBL10223070 | 0.79 | CCR9 (0.47) | PIK3CDCCR9 | |
| SCHEMBL14303638 | 0.77 | CCR9 (0.35) | CCR9 | |
| SCHEMBL10223574 | 0.77 | HSD17B2 (0.52) | CCR2CCR9 | |
| SCHEMBL306561 | 0.76 | HSD17B2 (0.51) | PIK3CDCCR9 | |
| SCHEMBL12594355 | 0.74 | MEN1 (0.47) | GPR27CCR2CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL4780581 | 0.74 | CCR2 (0.55) | GPR27POLBCCR2CYP1A2CYP3A4 | |
| SCHEMBL12161743 | 0.73 | LMNA (0.50) | GPR27POLBCCR2CYP1A2CYP3A4 | |
| SCHEMBL4774906 | 0.73 | KMT2A (0.53) | SLC40A1CCR2CYP2C9CCR4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008008431-A2 | HETEROARYL SULFONAMIDES AND CCR2/CCR9 | CHEMOCENTRYX, INC. (US) | 2008-01-17 | — | — | WO | disclosed |