SCHEMBL4795671

SCHEMBL4795671

COc1ccc(C(C)NC(=O)c2cc(Cl)ccc2NS(=O)(=O)c2ccccc2)cc1

nearest known ligand 0.60

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CCR9 P51686 2/20 0.57
KCNA5 P22460 5/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4795664 1.00 CCR9 (0.57) CCR9KCNA5
SCHEMBL14267573 1.00 CCR9 (0.57) CCR9KCNA5
SCHEMBL2481781 0.91 KCNA5 (0.65) KCNA5
SCHEMBL4799018 0.91 KCNA5 (0.65) KCNA5
SCHEMBL2476897 0.91 KCNA5 (0.65) KCNA5
SCHEMBL14267650 0.82 KCNA5 (0.68) KCNA5
SCHEMBL10249599 0.81 GPR27 (0.66) CCR9KCNA5
SCHEMBL10249221 0.79 ACLY (0.67) CCR9
SCHEMBL27857 0.79 LMNA (0.77) CCR9
SCHEMBL10249465 0.79 KCNA5 (0.82) CCR9KCNA5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7332608-B2 Anthranilamides and methods of their use SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) 2008-02-19 US disclosed
US-7235690-B2 Anthranilamides and methods of their use SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) 2007-06-26 US disclosed
US-20070117807-A1 ANTHRANILAMIDES AND METHODS OF THEIR USE SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) 2007-05-24 US disclosed
US-20030187033-A1 Anthranilamides and methods of their use SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) 2003-10-02 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070117807-A1 ANTHRANILAMIDES AND METHODS OF THEIR USE KCNH1, KCNH2, KCNJ2 CCR9 4872/4885KCNA5 10/4885
US-20030187033-A1 Anthranilamides and methods of their use KCNH1, KCNJ2, KCNH2 CCR9 4863/4885KCNA5 9/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.