Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.41 |
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.39 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | PDXK | O00764 | 2/20 | 0.39 |
| ▸ | AOX1 | Q06278 | 1/20 | 0.39 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.39 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.38 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 2/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2355840 | 0.80 | KDM4E (0.52) | KDM4ELMNAMAPTTSHRTP53 | |
| SCHEMBL3679899 | 0.80 | KDM4E (0.47) | KDM4ELMNAMAPTTSHRTP53 | |
| SCHEMBL3801869 | 0.79 | NOS2 (0.38) | CYP2A6P2RX7GABRA1GABRB2NOS3 | |
| SCHEMBL5742153 | 0.78 | RECQL (0.39) | KDM4ELMNAMAPTTSHRTP53 | |
| Hydrochloric Acid SCHEMBL28811005 | 0.78 | TRIM24 (0.51) | KDM4ELMNAMAPTTSHRTP53 | |
| SCHEMBL23012667 | 0.78 | NOS2 (0.54) | KDM4ELMNAMAPTTSHRTP53 | |
| SCHEMBL28714994 | 0.78 | KDM4E (0.39) | KDM4ELMNAMAPTTSHRTP53 | |
| SCHEMBL19641091 | 0.78 | KDM4E (0.39) | KDM4ELMNAMAPTTSHRTP53 | |
| SCHEMBL29439832 | 0.78 | KDM4E (0.39) | KDM4ELMNAMAPTTSHRTP53 | |
| SCHEMBL30032050 | 0.78 | RECQL (0.39) | KDM4ELMNAMAPTTSHRTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021212039-A1 | INHIBITORS OF CYSTEINE PROTEASES AND METHODS OF USE THEREOF | Pardes Biosciences, Inc. (US) | 2021-10-21 | — | — | WO | disclosed |
| WO-2008016811-A2 | AMINOPIPERIDINES AND REALTED COMPOUNDS | NEUROGEN CORPORATION (US) | 2008-02-07 | — | — | WO | disclosed |
| WO-2008016811-A2 | AMINOPIPERIDINES AND REALTED COMPOUNDS | NEUROGEN CORPORATION (US) | 2008-02-07 | — | — | WO | disclosed |
| US-20050239791-A1 | Substituted 1-heteroaryl-4-substituted piperazine and piperidine analogues | NEUROGEN CORPORATION | 2005-10-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050239791-A1 | Substituted 1-heteroaryl-4-substituted piperazine and piperidine analogues | MCHR1, MCHR2, PRLHR | KDM4E 1483/4885LMNA 3750/4885MAPT 3231/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.