Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | NOS3 | P29474 | 4/20 | 0.39 |
| ▸ | NOS2 | P35228 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 4/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | PDXK | O00764 | 1/20 | 0.37 |
| ▸ | AOX1 | Q06278 | 1/20 | 0.37 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.36 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.36 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28714994 | 1.00 | KDM4E (0.39) | KDM4ELMNATP53MAPTTSHR | |
| SCHEMBL26489048 | 0.81 | NOS2 (0.44) | KDM4EMAPTNOS3NOS2MEN1 | |
| SCHEMBL4795960 | 0.78 | KDM4E (0.41) | KDM4ELMNATP53MAPTTSHR | |
| SCHEMBL29259211 | 0.77 | GABRP (0.46) | KDM4ELMNAMAPTNOS3NOS2 | |
| SCHEMBL3679899 | 0.77 | KDM4E (0.47) | KDM4ELMNATP53MAPTTSHR | |
| SCHEMBL2355840 | 0.77 | KDM4E (0.52) | KDM4ELMNATP53MAPTTSHR | |
| SCHEMBL30073071 | 0.76 | NOS3 (0.36) | KDM4ENOS3NOS2HPGDHSD17B10 | |
| SCHEMBL23012667 | 0.75 | NOS2 (0.54) | KDM4ELMNATP53MAPTTSHR | |
| Hydrochloric Acid SCHEMBL28811005 | 0.75 | TRIM24 (0.51) | KDM4ELMNATP53MAPTTSHR | |
| SCHEMBL3940135 | 0.75 | RECQL (0.39) | KDM4ELMNATP53MAPTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3976597-A1 | SMALL MOLECULE INHIBITORS OF NF-KB INDUCING KINASE | Janssen Pharmaceutica NV (BE) | 2022-04-06 | — | — | EP | disclosed |