Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 5/20 | 0.61 |
| ▸ | DRD4 | P21917 | 3/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | UTS2R | Q9UKP6 | 3/20 | 0.53 |
| ▸ | DRD3 | P35462 | 3/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.51 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.51 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.51 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.51 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.51 |
| ▸ | DRD1 | P21728 | 1/20 | 0.51 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.51 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.51 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8105223 | 0.98 | HTR1A (0.62) | HTR1ADRD4MEN1KMT2AUTS2R | |
| SCHEMBL7432491 | 0.83 | HRH3 (0.47) | HTR1AMEN1KMT2AADRA1ALMNA | |
| SCHEMBL7983037 | 0.83 | GRIN2B (0.61) | HTR1ATSHRHIF1ASLC6A4ADRA1A | |
| SCHEMBL28753859 | 0.83 | HTR1A (0.61) | HTR1ASLC6A4SLC6A3 | |
| SCHEMBL13122653 | 0.83 | POLB (0.59) | CYP3A4TSHRPOLB | |
| SCHEMBL7547846 | 0.83 | HTR1A (0.61) | HTR1ASLC6A4SLC6A3 | |
| SCHEMBL5973113 | 0.83 | POLB (0.59) | CYP3A4TSHRPOLB | |
| SCHEMBL7357631 | 0.81 | HTR1A (0.62) | HTR1ACYP1A2SLC6A4SLC6A3DRD2 | |
| SCHEMBL4894490 | 0.81 | HRH3 (0.51) | HTR1AADRA1A | |
| SCHEMBL9094418 | 0.80 | DRD2 (0.61) | HTR1ADRD4MEN1KMT2ADRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008057543-A2 | UII-MODULATING COMPOUNDS AND THEIR USE | ACADIA PHARMACEUTICALS INC. (US) | 2008-05-15 | — | — | WO | disclosed |
| WO-2008057543-A2 | UII-MODULATING COMPOUNDS AND THEIR USE | ACADIA PHARMACEUTICALS INC. (US) | 2008-05-15 | — | — | WO | disclosed |