Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25928787 | 0.83 | HTT (0.36) | IDO1TDP1LMNAALDH1A1HPGD | |
| SCHEMBL4750832 | 0.82 | MAPT (0.50) | IDO1TDP1LMNAALDH1A1HPGD | |
| SCHEMBL30461968 | 0.82 | MAPT (0.50) | IDO1TDP1LMNAALDH1A1HPGD | |
| SCHEMBL16429615 | 0.79 | IDO1 (0.53) | IDO1TDP1LMNAALDH1A1HPGD | |
| SCHEMBL28125020 | 0.78 | MAPT (0.46) | IDO1TDP1LMNAALDH1A1HPGD | |
| SCHEMBL27922809 | 0.78 | ADRA2A (0.45) | IDO1TDP1LMNAALDH1A1HPGD | |
| SCHEMBL12223407 | 0.77 | ADRA2A (0.51) | IDO1TDP1LMNAALDH1A1MAPT | |
| SCHEMBL2962223 | 0.77 | TDP1 (0.57) | IDO1TDP1LMNAALDH1A1HPGD | |
| SCHEMBL6873187 | 0.76 | CYP1A2 (0.47) | IDO1TDP1LMNAALDH1A1HPGD | |
| SCHEMBL21141310 | 0.75 | ABL1 (0.46) | IDO1TDP1LMNAALDH1A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008033455-A2 | BIPHENYL AND HETEROARYL PHENYL DERIVATIVES AS PROTEIN TYROSINE PHOSPHATASES INHIBITORS | THE INSTITUTES FOR PHARMACEUTICAL DISCOVERY, LLC (US) | 2008-03-20 | — | — | WO | disclosed |