Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | GLA | P06280 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | TSPO | P30536 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1385749 | 0.88 | ALDH1A1 (0.62) | NPC1ALDH1A1GLAHTTRAB9A | |
| Hydrochloric Acid SCHEMBL27540694 | 0.86 | NPC1 (0.61) | NPC1ALDH1A1GLAHTTRAB9A | |
| SCHEMBL8001968 | 0.83 | TSPO (0.67) | NPC1ALDH1A1GLAHTTRAB9A | |
| SCHEMBL751298 | 0.83 | NPC1 (0.46) | NPC1ALDH1A1GLAHTTRAB9A | |
| SCHEMBL8009229 | 0.82 | NPC1 (0.57) | NPC1ALDH1A1GLAHTTRAB9A | |
| SCHEMBL8012651 | 0.82 | NPC1 (0.62) | NPC1ALDH1A1GLAHTTRAB9A | |
| SCHEMBL3763981 | 0.81 | LTB4R2 (0.56) | NPC1ALDH1A1GLAHTTRAB9A | |
| SCHEMBL27323388 | 0.80 | NPC1 (0.50) | NPC1ALDH1A1GLAHTTRAB9A | |
| SCHEMBL5370995 | 0.78 | ALOX5 (0.39) | ALDH1A1GLAHTTSMN1; SMN2TSHR | |
| SCHEMBL8016637 | 0.77 | ALOX5 (0.57) | NPC1ALDH1A1GLAHTTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107556267-A | Novel thiazole derivates class compound, its preparation method, pharmaceutical composition and its pharmaceutical applications | 中国人民解放军军事医学科学院毒物药物研究所 | 2018-01-09 | — | — | CN | disclosed |
| US-7427616-B2 | Condensed pyridines and pyrimidines with tie2 (TEK) activity | ASTRAZENECA AB (SE) | 2008-09-23 | — | — | US | disclosed |
| US-20050256140-A1 | Condensed pyridines and pyrimidines with tie2 (tek) activity | ASTRAZENECA AB (SE) | 2005-11-17 | — | — | US | disclosed |
| EP-1537112-A1 | CONDENSED PYRIDINES AND PYRIMIDINES WITH TIE2 (TEK) ACTIVITY | Astrazeneca AB (SE) | 2005-06-08 | — | — | EP | disclosed |
| WO-2004013141-A1 | CONDENSED PYRIDINES AND PYRIMIDINES WITH TIE2 (TEK) ACTIVITY | ASTRAZENECA AB (SE) | 2004-02-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050256140-A1 | Condensed pyridines and pyrimidines with tie2 (tek) activity | TIE1, TEK, KDR | NPC1 4851/4885ALDH1A1 2177/4885GLA 2582/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.