Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS2R14 | Q9NYV8 | 3/20 | 0.58 |
| ▸ | KEAP1 | Q14145 | 3/20 | 0.56 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.56 |
| ▸ | BMP1 | P13497 | 3/20 | 0.55 |
| ▸ | PTGES | O14684 | 1/20 | 0.53 |
| ▸ | TAS2R8 | Q9NYW2 | 1/20 | 0.53 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.53 |
| ▸ | MMP9 | P14780 | 4/20 | 0.52 |
| ▸ | MMP2 | P08253 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.51 |
| ▸ | PGR | P06401 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | MMP8 | P22894 | 1/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7346251 | 0.91 | KEAP1 (0.61) | TAS2R14KEAP1NFE2L2BMP1PTGES | |
| SCHEMBL7346255 | 0.91 | KEAP1 (0.61) | TAS2R14KEAP1NFE2L2BMP1PTGES | |
| SCHEMBL1873282 | 0.89 | BMP1 (0.56) | TAS2R14KEAP1NFE2L2BMP1MMP9 | |
| SCHEMBL6414515 | 0.87 | BMP1 (0.61) | TAS2R14BMP1MMP9MMP2MMP8 | |
| SCHEMBL2680842 | 0.87 | BMP1 (0.61) | TAS2R14BMP1MMP9MMP2MMP8 | |
| SCHEMBL7345045 | 0.85 | TAS2R14 (0.54) | TAS2R14KEAP1NFE2L2BMP1PTGES | |
| SCHEMBL7345042 | 0.85 | TAS2R14 (0.54) | TAS2R14KEAP1NFE2L2BMP1PTGES | |
| SCHEMBL8843343 | 0.84 | TAS2R14 (0.57) | TAS2R14KEAP1NFE2L2BMP1PTGES | |
| SCHEMBL6324459 | 0.82 | TAS2R14 (0.57) | TAS2R14KEAP1NFE2L2BMP1PTGES | |
| SCHEMBL22252350 | 0.82 | KEAP1 (0.74) | TAS2R14KEAP1NFE2L2BMP1MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1986657-A2 | METHOD OF TREATING A SUBJECT SUFFERING FROM DEGENERATIVE DISC DISEASE USING A MATRIX METALLOPROTEASE INHIBITOR | Discogen, LLC (US) | 2008-11-05 | — | — | EP | disclosed |
| WO-2007098099-A2 | METHOD OF TREATING A SUBJECT SUFFERING FROM DEGENERATIVE DISC DISEASE USING A MATRIX METALLOPROTEASE INHIBITOR | DISCOGEN, LLC (US) | 2007-08-30 | — | — | WO | disclosed |
| EP-1028716-A1 | METHOD FOR TREATING AND PREVENTING HEART FAILURE AND VENTRICULAR DILATATION | WARNER-LAMBERT COMPANY (US) | 2000-08-23 | — | — | EP | disclosed |
| WO-1998025597-A2 | METHOD FOR TREATING AND PREVENTING HEART FAILURE AND VENTRICULAR DILATATION | WARNER-LAMBERT COMPANY (US) | 1998-06-18 | — | — | WO | disclosed |