Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 3/20 | 0.61 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.61 |
| ▸ | BMP1 | P13497 | 3/20 | 0.60 |
| ▸ | TAS2R14 | Q9NYV8 | 3/20 | 0.60 |
| ▸ | MMP9 | P14780 | 5/20 | 0.59 |
| ▸ | MMP2 | P08253 | 4/20 | 0.59 |
| ▸ | PTGES | O14684 | 1/20 | 0.55 |
| ▸ | TAS2R8 | Q9NYW2 | 1/20 | 0.55 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.55 |
| ▸ | MMP8 | P22894 | 2/20 | 0.54 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.53 |
| ▸ | PGR | P06401 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | MMP13 | P45452 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7346251 | 1.00 | KEAP1 (0.61) | KEAP1NFE2L2BMP1TAS2R14MMP9 | |
| SCHEMBL4797698 | 0.91 | TAS2R14 (0.58) | KEAP1NFE2L2BMP1TAS2R14MMP9 | |
| SCHEMBL22252350 | 0.91 | KEAP1 (0.74) | KEAP1NFE2L2BMP1TAS2R14MMP9 | |
| SCHEMBL6414515 | 0.89 | BMP1 (0.61) | BMP1TAS2R14MMP9MMP2MMP8 | |
| SCHEMBL2680842 | 0.89 | BMP1 (0.61) | BMP1TAS2R14MMP9MMP2MMP8 | |
| SCHEMBL25297916 | 0.88 | MMP9 (0.77) | KEAP1NFE2L2BMP1MMP9MMP2 | |
| SCHEMBL25253016 | 0.88 | MMP9 (0.77) | KEAP1NFE2L2BMP1MMP9MMP2 | |
| SCHEMBL29521729 | 0.88 | MMP9 (0.77) | KEAP1NFE2L2BMP1MMP9MMP2 | |
| SCHEMBL7345045 | 0.87 | TAS2R14 (0.54) | KEAP1NFE2L2BMP1TAS2R14MMP9 | |
| SCHEMBL7345042 | 0.87 | TAS2R14 (0.54) | KEAP1NFE2L2BMP1TAS2R14MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0606046-B1 | Arylsulfonamido-substituted hydroxamic acids | CIBA GEIGY AG (CH) | 1997-10-08 | — | — | EP | disclosed |
| US-5646167-A | ADMINISTERED AS METALLOPROTEINASE INHIBITOR, ANTITUMOR OR ANTICARCINOGENIC AGENT | CIBA-GEIGY CORPORATION (US) | 1997-07-08 | — | — | US | disclosed |
| US-5552419-A | METALLOPROTEINASE INHIBITORS | CIBA-GEIGY CORPORATION (US) | 1996-09-03 | — | — | US | disclosed |
| US-5506242-A | METALLOELASTASE INHIBITOR; TREATS EMPHYSEMA | CIBA-GEIGY CORPORATION (US) | 1996-04-09 | — | — | US | disclosed |
| US-5455258-A | Useful as inhibitors of matrix-degrading metalloproteinase enzymes such as stromelysin and/or collegenase | CIBA-GEIGY CORPORATION (US) | 1995-10-03 | — | — | US | disclosed |
| EP-0606046-A1 | Arylsulfonamido-substituted hydroxamic acids | CIBA-GEIGY AG (CH) | 1994-07-13 | — | — | EP | disclosed |