Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 3/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7785467 | 0.94 | KDM4E (0.39) | PLA2G2AKDM4EHSD17B10MAPTCASP1 | |
| SCHEMBL7784131 | 0.89 | MAPT (0.39) | RAB9AKDM4ENPC1TP53MAPT | |
| SCHEMBL5107478 | 0.88 | NR4A2 (0.37) | MAOBKDM4ETP53MAPTALDH1A1 | |
| SCHEMBL6131929 | 0.88 | KMT2A (0.39) | PLA2G2AKDM4ENPC1ALDH1A1HPGD | |
| SCHEMBL26290022 | 0.88 | KDM4E (0.45) | KDM4EHSD17B10MAPTALDH1A1HPGD | |
| SCHEMBL3238390 | 0.88 | PLA2G2A (0.39) | PLA2G2ARAB9AKDM4ENPC1MAPT | |
| SCHEMBL6131938 | 0.86 | DHODH (0.40) | PLA2G2AKDM4EHSD17B10MAPTCASP1 | |
| SCHEMBL5097833 | 0.86 | MEN1 (0.40) | RAB9AKDM4EHSD17B10NPC1MAPT | |
| SCHEMBL1848196 | 0.85 | PLA2G2A (0.41) | PLA2G2AKDM4EHSD17B10TP53MAPT | |
| SCHEMBL6653085 | 0.85 | KMT2A (0.39) | RAB9AKDM4ENPC1TP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101346663-A | Photochromic 2H-naphthopyrans | TRANSITIONS OPTICAL INC (US) | 2009-01-14 | — | — | CN | disclosed |
| EP-1963918-A1 | PHOTOCHROMIC 2H-NAPHTHOPYRANS | TRANSITIONS OPTICAL, INC. (US) | 2008-09-03 | — | — | EP | disclosed |
| US-20070145337-A1 | Photochromic 2H-naphthopyrans | TRANSITIONS OPTICAL, INC. | 2007-06-28 | — | — | US | disclosed |
| WO-2007073463-A1 | PHOTOCHROMIC 2H-NAPHTHOPYRANS | TRANSITIONS OPTICAL, INC. (US) | 2007-06-28 | — | — | WO | disclosed |