Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.38 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | HPGD | P15428 | 4/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 5/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4798246 | 0.94 | PLA2G2A (0.41) | KDM4ECYP2C9CYP2C19CYP1A2CYP2D6 | |
| SCHEMBL1848196 | 0.91 | PLA2G2A (0.41) | KDM4ECYP2C9CYP2C19CYP1A2CYP2D6 | |
| SCHEMBL6131930 | 0.89 | L3MBTL1 (0.39) | KDM4ECYP2C9CYP2C19CYP1A2CYP2D6 | |
| SCHEMBL7971698 | 0.89 | MAPT (0.38) | KDM4ECYP2C9CYP2C19ALDH1A1HPGD | |
| SCHEMBL6131929 | 0.86 | KMT2A (0.39) | KDM4ECYP2C19PLA2G2AALDH1A1HPGD | |
| SCHEMBL7784131 | 0.85 | MAPT (0.39) | KDM4ECYP2C9CYP2C19ALDH1A1KMT2A | |
| SCHEMBL7784040 | 0.84 | KDM4E (0.35) | KDM4ECYP2C9CYP2C19CYP1A2CYP2D6 | |
| SCHEMBL1847688 | 0.84 | GABRG2 (0.37) | KDM4ECYP2C9CYP2C19CYP1A2CYP2D6 | |
| SCHEMBL5435358 | 0.83 | KMT2A (0.37) | KDM4ECYP2C9CYP2C19CYP1A2CYP2D6 | |
| SCHEMBL6653085 | 0.82 | KMT2A (0.39) | KDM4EALDH1A1HPGDKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140892-A1 | PHOTOCHROMIC SUBSTIITUTED 2H-NAPHTHO[1,2-B]PYRANS | JAMES ROBINSON LIMITED (GB) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000035902-A1 | PHOTOCHROMIC SUBSTITUTED 2H-NAPHTHO[1,2-b]PYRANS | JAMES ROBINSON LIMITED (GB) | 2000-06-22 | — | — | WO | disclosed |