Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F3 | P13726 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | NEK2 | P51955 | 1/20 | 0.38 |
| ▸ | F2RL1 | P55085 | 1/20 | 0.38 |
| ▸ | PARP14 | Q460N5 | 7/20 | 0.38 |
| ▸ | PARP1 | P09874 | 7/20 | 0.38 |
| ▸ | PARP10 | Q53GL7 | 6/20 | 0.38 |
| ▸ | PARP15 | Q460N3 | 4/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | TNKS | O95271 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.37 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4800027 | 0.89 | BRD4 (0.38) | F3NPC1TDP1MEN1KMT2A | |
| SCHEMBL4797749 | 0.88 | NPC1 (0.41) | F2RL1NPC1MEN1KMT2AMAPT | |
| SCHEMBL4801315 | 0.88 | EPHX2 (0.47) | NPC1MEN1KMT2AALDH1A1CYP1A2 | |
| SCHEMBL4800887 | 0.86 | NPC1 (0.39) | F2RL1NPC1TDP1MEN1KMT2A | |
| SCHEMBL4796292 | 0.85 | TSHR (0.50) | NPC1KMT2AALDH1A1SMN1; SMN2OPRK1 | |
| SCHEMBL4800960 | 0.84 | CTSL (0.47) | TDP1MEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL4796161 | 0.83 | CTSL (0.43) | — | |
| SCHEMBL4797850 | 0.82 | MME (0.36) | MEN1KMT2A | |
| SCHEMBL4798052 | 0.81 | CTSS (0.38) | NPC1SMN1; SMN2MGLL | |
| SCHEMBL4799139 | 0.81 | EPHX1 (0.36) | PARP10MGLL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080242671-A1 | INHIBITORS OF CATHEPSIN S | IRM LLC (BM) | 2008-10-02 | — | — | US | claimed |
| US-20080242671-A1 | INHIBITORS OF CATHEPSIN S | IRM LLC (BM) | 2008-10-02 | — | — | US | disclosed |
| US-7384970-B2 | Inhibitors of cathepsin S | IRM LLC (BM) | 2008-06-10 | — | — | US | disclosed |
| US-20040248887-A1 | Inhibitors of cathepsin S | IRM LLC (BM) | 2004-12-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040248887-A1 | Inhibitors of cathepsin S | CTSS, CTSB, CTSZ | F3 1428/4885CDK2 793/4885NEK2 3510/4885 |
| US-20080242671-A1 | INHIBITORS OF CATHEPSIN S | CTSS, CTSB, CTSZ | F3 1428/4885CDK2 793/4885NEK2 3510/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.