Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 1.00 |
| ▸ | RAB9A | P51151 | 4/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 1.00 |
| ▸ | MAPT | P10636 | 4/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 1.00 |
| ▸ | MEN1 | O00255 | 2/20 | 1.00 |
| ▸ | NFKB1 | P19838 | 2/20 | 1.00 |
| ▸ | NFKB2 | Q00653 | 2/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 2/20 | 1.00 |
| ▸ | RELA | Q04206 | 2/20 | 1.00 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 1.00 |
| ▸ | DHFR | P00374 | 1/20 | 0.39 |
| ▸ | BACE1 | P56817 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
| ▸ | KMO | O15229 | 2/20 | 0.38 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.38 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.38 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.38 |
| ▸ | MIF | P14174 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4779545 | 0.84 | RAB9A (1.00) | NPC1RAB9AKDM4EALDH1A1MAPT | |
| SCHEMBL4726303 | 0.76 | KDM4E (0.60) | NPC1RAB9AKDM4EALDH1A1MAPT | |
| SCHEMBL5413859 | 0.74 | KDM4E (0.59) | NPC1RAB9AKDM4EALDH1A1MAPT | |
| SCHEMBL7499663 | 0.73 | ALDH1A1 (0.61) | NPC1RAB9AKDM4EALDH1A1MAPT | |
| SCHEMBL5413864 | 0.71 | KDM4E (0.55) | NPC1RAB9AKDM4EALDH1A1MAPT | |
| SCHEMBL19748096 | 0.70 | KDM4E (0.57) | NPC1RAB9AKDM4EALDH1A1MAPT | |
| SCHEMBL5408690 | 0.68 | KDM4E (0.51) | NPC1RAB9AKDM4EALDH1A1MAPT | |
| SCHEMBL31669622 | 0.67 | NPC1 (0.50) | NPC1RAB9AKDM4EALDH1A1MAPT | |
| SCHEMBL2519357 | 0.66 | KDM4E (0.53) | NPC1RAB9AKDM4EALDH1A1MAPT | |
| SCHEMBL22139141 | 0.66 | MEN1 (0.49) | NPC1RAB9AKDM4EALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008029152-A2 | TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY | SUMMIT CORPORATION PLC (GB) | 2008-03-13 | — | — | WO | disclosed |