Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 7/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | F2 | P00734 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.32 |
| ▸ | CFTR | P13569 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 2/20 | 0.31 |
| ▸ | CA2 | P00918 | 2/20 | 0.31 |
| ▸ | CA12 | O43570 | 1/20 | 0.31 |
| ▸ | CA7 | P43166 | 1/20 | 0.31 |
| ▸ | CA9 | Q16790 | 1/20 | 0.31 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | CASP3 | P42574 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL51251 | 0.84 | TSHR (0.48) | TSHRLMNAALDH1A1HSD17B10CFTR | |
| SCHEMBL129333 | 0.79 | TSHR (0.55) | TSHRLMNAALDH1A1HSD17B10KDM4E | |
| SCHEMBL27464312 | 0.78 | TSHR (0.42) | TSHRLMNAALDH1A1HSD17B10CFTR | |
| SCHEMBL8673620 | 0.78 | TSHR (0.53) | TSHRLMNAALDH1A1HSD17B10KDM4E | |
| SCHEMBL130905 | 0.77 | ALDH1A1 (0.58) | TSHRLMNAALDH1A1HSD17B10TDP1 | |
| SCHEMBL27500893 | 0.77 | TSHR (0.41) | TSHRLMNAALDH1A1HSD17B10CFTR | |
| SCHEMBL11727225 | 0.76 | F2 (0.32) | TSHRLMNAF2TDP1 | |
| SCHEMBL130469 | 0.76 | PDCD1 (0.47) | TSHRLMNAALDH1A1HSD17B10KDM4E | |
| SCHEMBL2024418 | 0.76 | ALDH1A1 (0.38) | TSHRLMNAALDH1A1HSD17B10TDP1 | |
| SCHEMBL11281054 | 0.75 | MAPT (0.47) | LMNAALDH1A1TDP1CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040167102-A1 | Isoprenoid analog compounds and methods of making and use thereof | UNIVERSITY OF IOWA RESEARCH FOUNDATION. | 2004-08-26 | — | — | US | claimed |
| US-6727234-B2 | FOR BLOCKING PRENYLATION TRANSFERASE ENZYMES; ANTICANCER AGENTS; STABILITY | UNIVERSITY OF IOWA RESEARCH FOUNDATION | 2004-04-27 | — | — | US | claimed |
| US-20030022869-A1 | Isoprenoid analog compounds and methods of making and use thereof | UNIVERSITY OF IOWA RESEARCH FOUNDATION | 2003-01-30 | — | — | US | claimed |
| US-7414048-B2 | 4,5-dihydro-isoxazole derivatives and their pharmaceutical use | JANSSEN PHARMACEUTICA, N.V. (BE) | 2008-08-19 | — | — | US | disclosed |
| US-20040167102-A1 | Isoprenoid analog compounds and methods of making and use thereof | UNIVERSITY OF IOWA RESEARCH FOUNDATION. | 2004-08-26 | — | — | US | disclosed |
| US-6727234-B2 | FOR BLOCKING PRENYLATION TRANSFERASE ENZYMES; ANTICANCER AGENTS; STABILITY | UNIVERSITY OF IOWA RESEARCH FOUNDATION | 2004-04-27 | — | — | US | disclosed |
| US-6583141-B1 | T cell mediated rheumatic diseases | JANSSEN PHARMACEUTICA, N.V. (BE) | 2003-06-24 | — | — | US | disclosed |
| US-20030022869-A1 | Isoprenoid analog compounds and methods of making and use thereof | UNIVERSITY OF IOWA RESEARCH FOUNDATION | 2003-01-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030022869-A1 | Isoprenoid analog compounds and methods of making and use thereof | FNTA, RCE1, GGPS1 | TSHR 3524/4885LMNA 611/4885F2 370/4885 |
| US-20040167102-A1 | Isoprenoid analog compounds and methods of making and use thereof | FNTA, RCE1, GGPS1 | TSHR 3524/4885LMNA 611/4885F2 370/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.