SCHEMBL51251

SCHEMBL51251

COC(=O)c1[c]cccc1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.48
LMNA P02545 1/20 0.44
ALDH1A1 P00352 2/20 0.42
CFTR P13569 1/20 0.42
HSD17B10 Q99714 1/20 0.42
CA1 P00915 4/20 0.42
CA2 P00918 4/20 0.42
CA9 Q16790 3/20 0.42
CA12 O43570 2/20 0.42
CA7 P43166 2/20 0.42
CA14 Q9ULX7 2/20 0.42
KDM4E B2RXH2 1/20 0.41
POLB P06746 1/20 0.41
ATM Q13315 1/20 0.41
MAPT P10636 2/20 0.39
CASP3 P42574 1/20 0.39
RAB9A P51151 1/20 0.39
SENP8 Q96LD8 1/20 0.39
SENP7 Q9BQF6 1/20 0.39
SENP6 Q9GZR1 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27464312 0.93 TSHR (0.42) TSHRLMNAALDH1A1CFTRHSD17B10
SCHEMBL27500893 0.91 TSHR (0.41) TSHRLMNAALDH1A1CFTRHSD17B10
SCHEMBL4798982 0.84 TSHR (0.36) TSHRLMNAALDH1A1CFTRHSD17B10
SCHEMBL11421822 0.81 ALDH1A1 (0.40) TSHRLMNAALDH1A1HSD17B10CA1
SCHEMBL11727225 0.79 F2 (0.32) TSHRLMNAKMT2ATDP1
SCHEMBL129333 0.79 TSHR (0.55) TSHRLMNAALDH1A1HSD17B10CA1
SCHEMBL130469 0.79 PDCD1 (0.47) TSHRLMNAALDH1A1HSD17B10CA1
SCHEMBL8993152 0.79 CTSD (0.36) TSHRLMNAALDH1A1CFTRHSD17B10
SCHEMBL2024418 0.79 ALDH1A1 (0.38) TSHRLMNAALDH1A1HSD17B10CA1
SCHEMBL17416666 0.78 TSHR (0.32) TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 6129 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118324812-A Nitrogen-phosphine compound, and preparation method and application thereof 河南大学 2024-07-12 CN claimed
CN-118324806-A Diaryl alkyl phosphine and preparation method and application thereof 河南大学 2024-07-12 CN claimed
US-20240043689-A1 SEALANT COMPOSITION DOW SILICONES CORPORATION 2024-02-08 US claimed
CN-117304127-A Oxazoline derivative and preparation method and application thereof 南开大学 2023-12-29 CN claimed
WO-2023230217-A1 ANTILEISHMANIAL COMPOUNDS, COMPOSITIONS AND USE THEREOF TRUSTEES OF BOSTON UNIVERSITY (US) 2023-11-30 WO claimed
US-RE49735-E1 Oxazolidinones as modulators of MGLUR5 BRISTOL-MYERS SQUIBB COMPANY (US) 2023-11-28 US claimed
EP-3673027-B1 DUAL CURE ADHESIVE COMPOSITION AND METHODS FOR ITS PREPARATION AND USE DOW SILICONES CORP (US) 2023-11-01 EP claimed
EP-4267677-A1 SEALANT COMPOSITION Dow Silicones Corporation (US) 2023-11-01 EP claimed
CN-116730994-A Preparation method of 7-sulfonylated derivatives of eupatorium songaricum 潍坊医学院 2023-09-12 CN claimed
US-20230242520-A1 MALONITRILE DERIVATIVES HOFFMANN-LA ROCHE INC. (US) 2023-08-03 US claimed
US-4217448-A MONIC ACID DERIVATIVES BEECHAM GROUP LIMITED (GB) 1980-08-12 US claimed
US-4214093-A PROTEOLYTIC ENZYME INHIBITORS TORII & CO., LTD. (JP) 1980-07-22 US claimed
US-4213898-A FOR POLYACRYLONITRILE SANDOZ LTD. (CH) 1980-07-22 US claimed
EP-0012112-A1 Pressure-sensitive or heat-sensitive recording material CIBA-GEIGY AG (CH) 1980-06-11 EP claimed
US-4147693-A βLactam antibiotics and process for their use BAYER AKTIENGESELLSCHAFT (DE) 1979-04-03 US claimed
US-4049664-A ANTIALLERGENS, ANTIASTHMATICS FUJISAWA PHARMACEUTICAL CO., LTD. (JA) 1977-09-20 US claimed
US-4009206-A CHOLESTEROL LOWERING AGENTS MURAI HIROMU 1977-02-22 US claimed
US-3998803-A TEXTILES FIDELITY UNION TRUST COMPANY, EXECUTIVE TRUSTEE UNDER THE SANDOZ TRUST (US) 1976-12-21 US claimed
US-3965122-A ANTIALLERGENS FUJISAWA PHARMACEUTICAL CO., LTD. (JA) 1976-06-22 US claimed
US-3953464-A ANALGESICS, ANTIINFLAMMATORY AGENTS WARNER-LAMBERT COMPANY (US) 1976-04-27 US claimed