Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR2 | O95136 | 1/20 | 0.33 |
| ▸ | THRA | P10827 | 3/20 | 0.31 |
| ▸ | THRB | P10828 | 3/20 | 0.31 |
| ▸ | KMO | O15229 | 1/20 | 0.31 |
| ▸ | RHEB | Q15382 | 1/20 | 0.31 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.31 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL480149 | 0.91 | KDR (0.32) | — | |
| SCHEMBL480365 | 0.86 | CYP4F2 (0.37) | — | |
| SCHEMBL15789678 | 0.85 | MCL1 (0.35) | THRATHRBKMORHEBFFAR1 | |
| SCHEMBL480092 | 0.85 | PDE2A (0.34) | — | |
| SCHEMBL480320 | 0.84 | SCN9A (0.34) | RHEB | |
| SCHEMBL480107 | 0.84 | KMT2A (0.35) | — | |
| SCHEMBL480109 | 0.83 | PDK2 (0.36) | — | |
| SCHEMBL480000 | 0.80 | S1PR2 (0.33) | S1PR2THRATHRBKMOFFAR1 | |
| SCHEMBL479955 | 0.78 | IGFBP3 (0.35) | S1PR2THRATHRBRHEBEGLN1 | |
| SCHEMBL480182 | 0.77 | SCN9A (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2411361-A1 | 1,1,1-TRIFLUORO-2-HYDROXYPROPYL COMPOUNDS | F. Hoffmann-La Roche AG (CH) | 2012-02-01 | — | — | EP | disclosed |
| WO-2010108902-A1 | 1,1,1-TRIFLUORO-2-HYDROXYPROPYL COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2010-09-30 | — | — | WO | disclosed |