Known targets — ChEMBL curated mechanism
ABL1BMXBRAFBTKCHRNA4CHRNB2CSNK1EEGFRERBB2F10FLT1FLT3FLT4IGF1RINSRITKJAK3KDRKITOPRM1PARP1PARP2PDGFRBPIK3CDRAF1RETSLC18A2TECTXKdacAdacBdacCftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR known ✓ | P00533 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.60 |
| ▸ | TSHR | P16473 | 1/20 | 0.60 |
| ▸ | NT5E | P21589 | 1/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.52 |
| ▸ | ACHE | P22303 | 2/20 | 0.50 |
| ▸ | PKM | P14618 | 2/20 | 0.48 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.48 |
| ▸ | BCHE | P06276 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | F2 | P00734 | 1/20 | 0.46 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11052026 | 0.93 | ALDH1A1 (0.69) | ALDH1A1TSHRNT5ETDP1MAPK1 | |
| SCHEMBL11782818 | 0.88 | TSHR (0.78) | ALDH1A1TSHRNT5ETDP1MAPK1 | |
| SCHEMBL8421197 | 0.88 | TSHR (0.78) | ALDH1A1TSHRNT5ETDP1MAPK1 | |
| SCHEMBL11821857 | 0.88 | TSHR (0.78) | ALDH1A1TSHRNT5ETDP1MAPK1 | |
| SCHEMBL286762 | 0.84 | PKM (0.67) | ALDH1A1PKMLMNAF2PRSS1 | |
| SCHEMBL23364954 | 0.83 | ACHE (0.50) | ALDH1A1TDP1CYP3A4ACHEPKM | |
| SCHEMBL4399470 | 0.83 | ACHE (0.50) | ALDH1A1TDP1CYP3A4ACHEPKM | |
| SCHEMBL3347434 | 0.83 | ACHE (0.50) | ALDH1A1TDP1CYP3A4ACHEPKM | |
| SCHEMBL27224587 | 0.83 | ACHE (0.50) | ALDH1A1TDP1CYP3A4ACHEPKM | |
| SCHEMBL27972154 | 0.83 | ACHE (0.50) | ALDH1A1TDP1CYP3A4ACHEPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7318351-B2 | Pressure sensor | HONEYWELL INTERNATIONAL INC. (US) | 2008-01-15 | — | — | US | disclosed |
| WO-2007044307-A1 | A PIEZORESISTIVE PRESSURE SENSOR COMPRISING A PLASTIC PACKAGE | HONEYWELL INTERNATIONAL INC. (US) | 2007-04-19 | — | — | WO | disclosed |
| US-20070074577-A1 | Pressure sensor | HONEYWELL INTERNATIONAL INC. | 2007-04-05 | — | — | US | disclosed |
| US-3985772-A | 3-Amidinocoumarin dyes | BASF AKTIENGESELLSCHAFT (DT) | 1976-10-12 | — | — | US | disclosed |