Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | DAO | P14920 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 4/20 | 0.42 |
| ▸ | RAB9A | P51151 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | FLT3 | P36888 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.41 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4795138 | 0.90 | RAB9A (0.46) | KDM4EMAPTDAOHPGDSRD5A2 | |
| SCHEMBL4797498 | 0.89 | KDM4E (0.42) | KDM4EMAPTDAOHPGDSRD5A2 | |
| SCHEMBL4797332 | 0.84 | MAPT (0.44) | KDM4EMAPTNPC1RAB9AKMT2A | |
| SCHEMBL4797913 | 0.83 | HSD17B10 (0.44) | KDM4EMAPTDAOHPGDSRD5A2 | |
| SCHEMBL4798176 | 0.80 | GRM1 (0.55) | KDM4EMAPTHPGDHSD17B10NPC1 | |
| SCHEMBL4797456 | 0.75 | GRM1 (0.48) | KDM4EMAPTHPGDHSD17B10NPC1 | |
| SCHEMBL4800674 | 0.74 | GRM1 (0.57) | KDM4EMAPTNPC1RAB9AKMT2A | |
| SCHEMBL4795401 | 0.74 | GRM1 (0.61) | KDM4EMAPTNPC1RAB9AKMT2A | |
| SCHEMBL3337375 | 0.73 | MAPT (0.61) | KDM4EMAPTHPGDNPC1RAB9A | |
| SCHEMBL4799960 | 0.72 | GRM1 (0.63) | KDM4EMAPTHPGDHSD17B10NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008052804-A1 | THIAZOLHYDRAZIDES FOR TREATMENT OF NEURODEGENERATIVE DISEASES | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2008-05-08 | — | — | WO | claimed |
| WO-2008052804-A1 | THIAZOLHYDRAZIDES FOR TREATMENT OF NEURODEGENERATIVE DISEASES | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2008-05-08 | — | — | WO | disclosed |