Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | UCHL1 | P09936 | 1/20 | 0.49 |
| ▸ | PDE1A | P54750 | 3/20 | 0.47 |
| ▸ | PDE1B | Q01064 | 3/20 | 0.47 |
| ▸ | PDE1C | Q14123 | 3/20 | 0.47 |
| ▸ | GAA | P10253 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | CASP1 | P29466 | 1/20 | 0.46 |
| ▸ | CASP7 | P55210 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12604349 | 0.90 | UCHL1 (0.51) | UCHL1PDE1APDE1BPDE1CGAA | |
| SCHEMBL1363026 | 0.85 | KMT2A (0.52) | ALDH1A1USP2MAPK1NPSR1HSD17B10 | |
| SCHEMBL12604334 | 0.82 | UCHL1 (0.51) | UCHL1PDE1APDE1BPDE1CGAA | |
| SCHEMBL587425 | 0.81 | PDE4B (0.60) | UCHL1GAAALDH1A1PDE4BMAPT | |
| SCHEMBL4930818 | 0.76 | KMT2A (0.53) | ALDH1A1USP2MAPK1NPSR1HSD17B10 | |
| SCHEMBL8229160 | 0.76 | PDE4B (0.42) | ALDH1A1KDM4EUSP2HPGDMAPK1 | |
| SCHEMBL582644 | 0.74 | PDE4B (0.60) | UCHL1PDE1APDE1BPDE1CGAA | |
| SCHEMBL1695262 | 0.74 | MAT2A (0.61) | UCHL1PDE1APDE1BPDE1CGAA | |
| SCHEMBL221404 | 0.73 | ALDH1A1 (0.63) | ALDH1A1KDM4EUSP2HPGDMAPK1 | |
| SCHEMBL12604343 | 0.73 | LMNA (0.48) | PDE1APDE1BPDE1CALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008075007-A1 | MORPHOLINO-SUBSTITUTED BICYCLOHETEROARYL COMPOUNDS AND THEIR USE AS ANTI CANCER AGENTS | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2008-06-26 | — | — | WO | disclosed |