SCHEMBL480297

SCHEMBL480297

COC(=O)c1ccc(CBr)c(Cl)c1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 6/20 0.50
CA12 O43570 2/20 0.47
CA1 P00915 2/20 0.47
CA2 P00918 2/20 0.47
CA7 P43166 2/20 0.47
CA9 Q16790 2/20 0.47
CA14 Q9ULX7 2/20 0.47
XDH P47989 1/20 0.47
SMN1; SMN2 Q16637 3/20 0.47
TSHR P16473 2/20 0.47
CYP1A2 P05177 1/20 0.47
CYP2C19 P33261 1/20 0.47
PDK1 Q15118 2/20 0.45
PDK2 Q15119 2/20 0.45
PDK3 Q15120 2/20 0.45
PDK4 Q16654 2/20 0.45
KDM4E B2RXH2 3/20 0.44
MAPT P10636 6/20 0.44
MEN1 O00255 2/20 0.44
KMT2A Q03164 2/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28752184 0.87 ALDH1A1 (0.48) ALDH1A1CA12CA1CA2CA7
SCHEMBL30231055 0.87 ALDH1A1 (0.54) ALDH1A1CA12CA1CA2CA7
SCHEMBL694449 0.87 ALDH1A1 (0.54) ALDH1A1CA12CA1CA2CA7
SCHEMBL15778501 0.86 ALDH1A1 (0.53) ALDH1A1CA12CA1CA2CA7
SCHEMBL7651523 0.85 ALDH1A1 (0.51) ALDH1A1CA12CA1CA2CA7
SCHEMBL29559628 0.84 CA1 (0.52) ALDH1A1CA12CA1CA2CA7
SCHEMBL1028046 0.84 CA1 (0.52) ALDH1A1CA12CA1CA2CA7
SCHEMBL6300062 0.84 CA12 (0.53) ALDH1A1CA12CA1CA2CA7
SCHEMBL2948380 0.83 LOXL2 (0.54) ALDH1A1CA12CA1CA2CA7
SCHEMBL2480129 0.83 STAT3 (0.41) CA12CA1CA2CA9CA14

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 259 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2026098548-A1 PROTEIN DEGRADATION AGENT, PHARMACEUTICAL COMPOSITION COMPRISING SAME, USE THEREOF, AND METHOD 四川科伦博泰生物医药股份有限公司 2026-05-15 WO disclosed
US-20260125400-A1 TYK2 DEGRADERS AND USES THEREOF KYMERA THERAPEUTICS INC (US) 2026-05-07 US disclosed
US-12583839-B2 PD-L1 antagonist compound ADLAI NORTYE BIOPHARMA CO., LTD. (CN) 2026-03-24 US disclosed
WO-2025201504-A1 KAT6 INHIBITORS BEIGENE (SUZHOU) CO., LTD. (CN) 2025-10-02 WO disclosed
US-20250304535-A1 KAT6 Inhibitors BEIGENE SWITZERLAND GMBH (CH) 2025-10-02 US disclosed
US-20250263402-A1 BENZIMIDAZOLONE GLP-1 RECEPTOR AGONIST AND USE THEREOF HANGZHOU ZHONGMEIHUADONG PHARMACEUTICAL CO., LTD. (CN) 2025-08-21 US disclosed
US-20250059183-A1 PYRIDINE[4,3-D]PYRIMIDINE COMPOUND AS TLR7/8 AGONIST SHANGHAI VISONPHARMA CO., LTD. (CN) 2025-02-20 US disclosed
WO-2024220937-A2 TYK2 DEGRADERS AND USES THEREOF KYMERA THERAPEUTICS, INC. (US) 2024-10-24 WO disclosed
EP-4446323-A1 PYRIDINE[4,3-D]PYRIMIDINE COMPOUND AS TLR7/8 AGONIST Shanghai Visonpharma Co., Ltd. (CN) 2024-10-16 EP disclosed
CN-118382625-A Pyridine [4,3-d ] pyrimidines as TLR7/8 agonists 上海维申医药有限公司 2024-07-23 CN disclosed
US-4997844-A Compounds for the treatment of allergic or inflammatory diseases or shock conditions ICI AMERICAS INC. (US) 1991-03-05 US disclosed
EP-0403158-A2 Imidazolyl-alkenoic acids SMITHKLINE BEECHAM CORPORATION (US) 1990-12-19 EP disclosed
EP-0403159-A2 Imidazolyl-alkenoic acids SMITHKLINE BEECHAM CORPORATION (US) 1990-12-19 EP disclosed
EP-0179619-B1 HETEROCYCLIC AMIDES ICI AMERICAS INC. (US) 1990-09-05 EP disclosed
US-4753962-A HYPOGLYCEMIC, ANTIOBESITY AGENT BEECHAM GROUP P.L.C. (GB) 1988-06-28 US disclosed
US-4654371-A ANTI-OBESITY, HYPOGLYCEMIA AGENTS BEECHAM GROUP P.L.C. (GB) 1987-03-31 US disclosed
EP-0179619-A1 Heterocyclic amides ICI AMERICAS INC. (US) 1986-04-30 EP disclosed
US-4478849-A HYPERGLYCEMIC AGENTS BEECHAM GROUP LIMITED (GB) 1984-10-23 US disclosed
EP-0006735-B1 SECONDARY AMINES, THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE BEECHAM GROUP PLC (GB) 1983-06-15 EP disclosed
EP-0006735-A1 Secondary amines, their preparation, pharmaceutical compositions containing them and their use BEECHAM GROUP PLC (GB) 1980-01-09 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260125400-A1 TYK2 DEGRADERS AND USES THEREOF TYK2, CSNK2A1, CSNK2A2 ALDH1A1 3930/4885CA12 2592/4885CA1 2874/4885
US-20250263402-A1 BENZIMIDAZOLONE GLP-1 RECEPTOR AGONIST AND USE THEREOF GLP1R, GIPR, GCGR ALDH1A1 2478/4885CA12 4761/4885CA1 4621/4885
US-20250304535-A1 KAT6 Inhibitors KAT6A, KAT6B, KAT2A ALDH1A1 2832/4885CA12 2995/4885CA1 1153/4885
US-12583839-B2 PD-L1 antagonist compound CD274, PDCD1LG2, PDCD1 ALDH1A1 747/4885CA12 1349/4885CA1 1594/4885
US-20250059183-A1 PYRIDINE[4,3-D]PYRIMIDINE COMPOUND AS TLR7/8 AGONIST TLR7, TLR8, TLR1 ALDH1A1 2284/4885CA12 4875/4885CA1 4874/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.