Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 3/20 | 0.35 |
| ▸ | CA1 | P00915 | 3/20 | 0.35 |
| ▸ | CA2 | P00918 | 3/20 | 0.35 |
| ▸ | CA7 | P43166 | 3/20 | 0.35 |
| ▸ | CA9 | Q16790 | 3/20 | 0.35 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.35 |
| ▸ | ESR1 | P03372 | 1/20 | 0.35 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.34 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL416292 | 1.00 | KDM4E (0.41) | KDM4EMAPTKMT2AALOX15MEN1 | |
| SCHEMBL234027 | 0.74 | KDM4E (0.55) | KDM4EMAPTKMT2AALOX15MEN1 | |
| SCHEMBL28283233 | 0.74 | KDM4E (0.55) | KDM4EMAPTKMT2AALOX15MEN1 | |
| SCHEMBL21950883 | 0.73 | KDM4E (0.43) | KDM4EMAPTKMT2AALOX15MEN1 | |
| SCHEMBL317949 | 0.73 | MAPT (0.50) | KDM4EMAPTKMT2AALOX15MEN1 | |
| SCHEMBL2620018 | 0.73 | MAPT (0.50) | KDM4EMAPTKMT2AALOX15MEN1 | |
| SCHEMBL20450103 | 0.73 | OAT (0.33) | — | |
| SCHEMBL5658455 | 0.71 | ALDH1A1 (0.41) | KDM4EMAPTKMT2AALOX15MEN1 | |
| SCHEMBL7566870 | 0.70 | MAPT (0.47) | KDM4EMAPTKMT2AALOX15MEN1 | |
| SCHEMBL7567655 | 0.70 | MAPT (0.47) | KDM4EMAPTKMT2AALOX15MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2411362-A2 | INDOLE DERIVATIVES | GE Healthcare UK Limited (GB) | 2012-02-01 | — | — | EP | disclosed |
| WO-2010109007-A2 | INDOLE DERIVATIVES | GE HEALTHCARE LIMITED (GB) | 2010-09-30 | — | — | WO | disclosed |