SCHEMBL480352

SCHEMBL480352

O=C(O)c1c2c(c3ccccc3c1C(=O)O)CCCC2

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CDC7 O00311 1/20 0.48
EEF2K O00418 1/20 0.48
PLK4 O00444 1/20 0.48
DYRK3 O43781 1/20 0.48
PRKD3 O94806 1/20 0.48
MAP4K4 O95819 1/20 0.48
PRKCG P05129 1/20 0.48
AXL P30530 1/20 0.48
AKT1 P31749 1/20 0.48
AKT2 P31751 1/20 0.48
SYK P43405 1/20 0.48
MAPKAPK2 P49137 1/20 0.48
CLK2 P49760 1/20 0.48
GSK3B P49841 1/20 0.48
RPS6KA3 P51812 1/20 0.48
PLK1 P53350 1/20 0.48
CSNK2A1 P68400 1/20 0.48
CSNK1G2 P78368 1/20 0.48
BTK Q06187 1/20 0.48
TYRO3 Q06418 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3458298 0.98 CDC7 (0.47) CDC7EEF2KPLK4DYRK3PRKD3
SCHEMBL3661809 0.96 CDC7 (0.44) CDC7EEF2KPLK4DYRK3PRKD3
SCHEMBL84141 0.92 CDC7 (0.46) CDC7EEF2KPLK4DYRK3PRKD3
SCHEMBL6682958 0.81 KDM4E (0.50) CDC7EEF2KPLK4DYRK3PRKD3
SCHEMBL15845324 0.81 KDM4E (0.51) CDC7EEF2KPLK4DYRK3PRKD3
SCHEMBL5432747 0.81 FOLH1 (0.44) CDC7EEF2KPLK4DYRK3PRKD3
SCHEMBL7604525 0.77 WDR5 (0.50) CDC7EEF2KPLK4DYRK3PRKD3
SCHEMBL54422 0.76 KDM4E (0.58) ALDH1A1KDM4EMEN1KMT2AHPGD
SCHEMBL7603901 0.76 KDM4E (0.47) CDC7EEF2KPLK4DYRK3PRKD3
SCHEMBL11217935 0.74 KDM4E (0.48) CDC7EEF2KPLK4DYRK3PRKD3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 364 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20200299487-A1 FIBERS TREATED WITH POLYMERIZATION COMPOUNDS AND FIBER REINFORCED COMPOSITES MADE THEREFROM JOHNS MANVILLE 2020-09-24 US claimed
CN-111542421-A Thermoplastic material 翁贝托·基亚内塞 2020-08-14 CN claimed
US-9925553-B2 Method for forming bezel pattern of display substrate LG CHEM, LTD. (KR) 2018-03-27 US claimed
EP-2296581-B1 A BIOMATERIAL COLOPLAST AS (DK) 2017-11-15 EP claimed
US-20160213602-A1 POLYMER COMPOSITION FOR HIGH-HEAT APPLICATION COMPRISING THERMO-RELEASABLE SUBSTANCE DSM IP ASSETS B.V. (NL) 2016-07-28 US claimed
EP-3038490-A1 POLYMER COMPOSITION FOR HIGH-HEAT APPLICATION COMPRISING THERMO-RELEASABLE SUBSTANCE DSM IP Assets B.V. (NL) 2016-07-06 EP claimed
US-9381534-B2 Method for forming bezel pattern of display substrate LG CHEM, LTD. (KR) 2016-07-05 US claimed
US-20160168321-A1 HEAT RESISTANT POLYETHYLENE TEREPHTHALATE AND A PROCESS FOR THE PREPARATION OF THE SAME ESTER INDUSTRIES LIMITED (IN) 2016-06-16 US claimed
EP-2999733-A1 HEAT RESISTANT POLYETHYLENE TEREPHTHALATE AND A PROCESS FOR THE PREPARATION OF THE SAME Ester Industries Limited (IN) 2016-03-30 EP claimed
US-20150218394-A1 PRINTED MATTER AND METHOD FOR MANUFACTURING SUCH PRINTED MATTER LG CHEM, LTD. (KR) 2015-08-06 US claimed
US-20020061377-A1 Layers of thermoplastic polyester, one layer is harder than the others, thermoplastic polyester elastomer layer(s), and innermost polyolefin or polyamide layer; thermal aging resistance; low brittleness; for gasoline RASMUSSEN GMBH 2002-05-23 US claimed
US-6294234-B1 Fluid conduit for fuels and fuel vapors RASMUSSEN GMBH (DE) 2001-09-25 US claimed
EP-0841149-B1 Method for manufacturing articles from a polymer blend BOCK ORTHOPAED IND (DE) 2001-07-04 EP claimed
WO-2001023474-A2 POLYMER BLENDS CONTAINING MODIFIED POLYESTERS BAYER AKTIENGESELLSCHAFT (DE) 2001-04-05 WO claimed
EP-0848732-B1 TOUGHENED THERMOPLASTIC POLYMER COMPOSITIONS DU PONT (US) 2001-01-24 EP claimed
US-6018086-A SEPARATING A FEEDSTOCK INTO NAPHTHALENE, MONOALKYLNAPHTHALENE AND DIALKYLNAPHTHALENE FRACTIONS; SEPARATING AND PURIFYING 2,6-DIALKYLNAPHTHALENE FROM THAT FEEDSTOCK; ALKYLATING MONOALKYLNAPHTHALENES, TRANSALKYLATING NAPHTHALENE KABUSHIKI KAISHA KOBE SEIKO SHO (JP) 2000-01-25 US claimed
US-6011190-A TRANSALKYLATING ISOMERS OF DIALKYLNAPHTHALENE AND NAPHTHALENE TO PRODUCE MONOALKYLNAPHTHALENE AND ISOMERS OF DIALKYLNAPHTHALENE; ALKYLATING THE MONOALKYLNAPHTHALENE FRACTION TO PRODUCE DIALKYLNAPHTHALENE KABUSHIKI KAISHA KOBE SEIKO SHO (JP) 2000-01-04 US claimed
EP-0889016-A1 Process for preparing dialkylnaphthalene KABUSHIKI KAISHA KOBE SEIKO SHO also known as Kobe Steel Ltd. (JP) 1999-01-07 EP claimed
US-5548259-A Electromagnetic relay having an improved resistivity to surge NEC CORPORATION (JP) 1996-08-20 US claimed
EP-0386256-B1 AROMATIC POLYESTER RESIN COMPOSITION AND FIBERS THEREOF TEIJIN LTD (JP) 1996-05-01 EP claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160213602-A1 POLYMER COMPOSITION FOR HIGH-HEAT APPLICATION COMPRISING THERMO-RELEASABLE SUBSTANCE HSPB1, HSP90AB1, COL1A1 CDC7 973/4885EEF2K 1726/4885PLK4 651/4885
US-20200299487-A1 FIBERS TREATED WITH POLYMERIZATION COMPOUNDS AND FIBER REINFORCED COMPOSITES MADE THEREFROM NEFM, VCL, SAMM50 CDC7 1721/4885EEF2K 1703/4885PLK4 1554/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.