Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACLY | P53396 | 1/20 | 0.47 |
| ▸ | RORC | P51449 | 2/20 | 0.46 |
| ▸ | DHODH | Q02127 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.44 |
| ▸ | PDK1 | Q15118 | 4/20 | 0.43 |
| ▸ | PDK2 | Q15119 | 4/20 | 0.43 |
| ▸ | PDK3 | Q15120 | 4/20 | 0.43 |
| ▸ | PDK4 | Q16654 | 4/20 | 0.43 |
| ▸ | RORB | Q92753 | 1/20 | 0.42 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.42 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.42 |
| ▸ | TRPM4 | Q8TD43 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14083203 | 0.86 | TRPV1 (0.52) | TRPV1NTRK1 | |
| SCHEMBL4179499 | 0.83 | KDM4E (0.51) | KDM4ETDP1TRPV1PDK1PDK2 | |
| SCHEMBL14083192 | 0.82 | TRPV1 (0.54) | KDM4ETRPV1 | |
| SCHEMBL4812253 | 0.82 | ACLY (0.57) | ACLYKDM4EKDM4CTRPM4 | |
| SCHEMBL14082109 | 0.81 | SMN1; SMN2 (0.45) | ACLYRORCDHODHKDM4ETRPV1 | |
| SCHEMBL14083223 | 0.80 | TRPV1 (0.48) | TRPV1 | |
| SCHEMBL14083213 | 0.80 | TRPV1 (0.53) | TRPV1LMNASMN1; SMN2 | |
| SCHEMBL4182257 | 0.80 | KDM4E (0.47) | RORCDHODHKDM4ETDP1TRPV1 | |
| SCHEMBL4809441 | 0.80 | KDM4E (0.47) | ACLYRORCKDM4ETDP1TRPV1 | |
| SCHEMBL14083207 | 0.79 | TRPV1 (0.70) | TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080200524-A1 | Amide compounds as ion channel ligands and uses thereof | KELLY MICHAEL G | 2008-08-21 | — | — | US | disclosed |
| US-20080200524-A1 | Amide compounds as ion channel ligands and uses thereof | KELLY MICHAEL G | 2008-08-21 | — | — | US | disclosed |
| US-20080200524-A1 | Amide compounds as ion channel ligands and uses thereof | KELLY MICHAEL G | 2008-08-21 | — | — | US | disclosed |
| US-7338950-B2 | Amide compounds as ion channel ligands and uses thereof | RENOVIS, INC. (US) | 2008-03-04 | — | — | US | disclosed |
| US-7338950-B2 | Amide compounds as ion channel ligands and uses thereof | RENOVIS, INC. (US) | 2008-03-04 | — | — | US | disclosed |
| US-7338950-B2 | Amide compounds as ion channel ligands and uses thereof | RENOVIS, INC. (US) | 2008-03-04 | — | — | US | disclosed |
| EP-1685109-A2 | AMIDE COMPOUNDS AS ION CHANNEL LIGANDS AND USES THEREOF | Renovis, Inc. (US) | 2006-08-02 | — | — | EP | disclosed |
| US-20050197364-A1 | Amide compounds as ion channel ligands and uses thereof | RENOVIS, INC. | 2005-09-08 | — | — | US | disclosed |
| US-20050192293-A1 | Amide compounds as ion channel ligands and uses thereof | RENOVIS, INC. | 2005-09-01 | — | — | US | disclosed |
| WO-2005034870-A2 | AMIDE COMPOUNDS AND ION CHANNEL LIGANDS AND USES THEREOF | RENOVIS, INC. (US) | 2005-04-21 | — | — | WO | disclosed |
| WO-2005032493-A2 | AMIDE COMPOUNDS AS ION CHANNEL LIGANDS AND USES THEREOF | RENOVIS, INC. (US) | 2005-04-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080200524-A1 | Amide compounds as ion channel ligands and uses thereof | TRPV1, TRPA1, TRPV2 | ACLY 758/4885RORC 2787/4885DHODH 3640/4885 |
| US-20050197364-A1 | Amide compounds as ion channel ligands and uses thereof | TRPV1, TRPA1, TRPV2 | ACLY 758/4885RORC 2787/4885DHODH 3640/4885 |
| US-20050192293-A1 | Amide compounds as ion channel ligands and uses thereof | TRPV1, TRPA1, TRPV2 | ACLY 758/4885RORC 2787/4885DHODH 3640/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.