Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | PPM1B | O75688 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.45 |
| ▸ | RORB | Q92753 | 1/20 | 0.45 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.44 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.44 |
| ▸ | RORC | P51449 | 2/20 | 0.44 |
| ▸ | PDK1 | Q15118 | 4/20 | 0.43 |
| ▸ | PDK2 | Q15119 | 4/20 | 0.43 |
| ▸ | PDK3 | Q15120 | 4/20 | 0.43 |
| ▸ | PDK4 | Q16654 | 4/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | KMO | O15229 | 1/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | HAVCR2 | Q8TDQ0 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4179499 | 0.87 | KDM4E (0.51) | KDM4ETDP1LMNASMN1; SMN2RORB | |
| SCHEMBL14083348 | 0.83 | TRPV1 (0.59) | NTRK1TRPV1KMT2A | |
| SCHEMBL4182257 | 0.83 | KDM4E (0.47) | KDM4ETDP1LMNASMN1; SMN2NAPRT | |
| SCHEMBL4816413 | 0.82 | DPP4 (0.46) | KDM4ETDP1LMNASMN1; SMN2NAPRT | |
| SCHEMBL15048943 | 0.80 | KDM4E (0.47) | KDM4ETDP1LMNASMN1; SMN2NAPRT | |
| SCHEMBL14083352 | 0.80 | TRPV1 (0.61) | NTRK1TRPV1KMT2A | |
| SCHEMBL4908258 | 0.80 | TRPV1 (0.67) | KDM4ETRPV1RORCPDK1PDK2 | |
| SCHEMBL4805652 | 0.80 | ACLY (0.47) | KDM4ETDP1LMNASMN1; SMN2RORB | |
| SCHEMBL14083366 | 0.78 | TRPV1 (0.53) | NTRK1TRPV1 | |
| SCHEMBL14083364 | 0.77 | TRPV1 (0.55) | NTRK1TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080200524-A1 | Amide compounds as ion channel ligands and uses thereof | KELLY MICHAEL G | 2008-08-21 | — | — | US | disclosed |
| US-20080200524-A1 | Amide compounds as ion channel ligands and uses thereof | KELLY MICHAEL G | 2008-08-21 | — | — | US | disclosed |
| US-20080200524-A1 | Amide compounds as ion channel ligands and uses thereof | KELLY MICHAEL G | 2008-08-21 | — | — | US | disclosed |
| US-7338950-B2 | Amide compounds as ion channel ligands and uses thereof | RENOVIS, INC. (US) | 2008-03-04 | — | — | US | disclosed |
| US-7338950-B2 | Amide compounds as ion channel ligands and uses thereof | RENOVIS, INC. (US) | 2008-03-04 | — | — | US | disclosed |
| US-7338950-B2 | Amide compounds as ion channel ligands and uses thereof | RENOVIS, INC. (US) | 2008-03-04 | — | — | US | disclosed |
| EP-1685109-A2 | AMIDE COMPOUNDS AS ION CHANNEL LIGANDS AND USES THEREOF | Renovis, Inc. (US) | 2006-08-02 | — | — | EP | disclosed |
| US-20050197364-A1 | Amide compounds as ion channel ligands and uses thereof | RENOVIS, INC. | 2005-09-08 | — | — | US | disclosed |
| US-20050192293-A1 | Amide compounds as ion channel ligands and uses thereof | RENOVIS, INC. | 2005-09-01 | — | — | US | disclosed |
| WO-2005034870-A2 | AMIDE COMPOUNDS AND ION CHANNEL LIGANDS AND USES THEREOF | RENOVIS, INC. (US) | 2005-04-21 | — | — | WO | disclosed |
| WO-2005032493-A2 | AMIDE COMPOUNDS AS ION CHANNEL LIGANDS AND USES THEREOF | RENOVIS, INC. (US) | 2005-04-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080200524-A1 | Amide compounds as ion channel ligands and uses thereof | TRPV1, TRPA1, TRPV2 | KDM4E 4231/4885TDP1 4448/4885PPM1B 3823/4885 |
| US-20050197364-A1 | Amide compounds as ion channel ligands and uses thereof | TRPV1, TRPA1, TRPV2 | KDM4E 4231/4885TDP1 4448/4885PPM1B 3823/4885 |
| US-20050192293-A1 | Amide compounds as ion channel ligands and uses thereof | TRPV1, TRPA1, TRPV2 | KDM4E 4231/4885TDP1 4448/4885PPM1B 3823/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.