Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.40 |
| ▸ | TUBB | P07437 | 1/20 | 0.40 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.40 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.40 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.40 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.40 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.40 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.40 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.40 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5352406 | 0.80 | KMT2A (0.56) | KMT2AALDH1A1TDP1POLBMAPT | |
| SCHEMBL5357893 | 0.80 | ALDH1A1 (0.45) | KMT2AALDH1A1POLBMAPTKDM4E | |
| SCHEMBL5352984 | 0.80 | KMT2A (0.47) | KMT2AALDH1A1TDP1POLBMAPT | |
| SCHEMBL4806409 | 0.78 | KMT2A (0.51) | KMT2AALDH1A1TDP1POLBMAPT | |
| SCHEMBL5643991 | 0.78 | KMT2A (0.51) | KMT2AALDH1A1TDP1POLBMAPT | |
| SCHEMBL4807666 | 0.77 | GRIA2 (0.48) | KMT2AALDH1A1TDP1POLBMAPT | |
| SCHEMBL5624476 | 0.77 | ALDH1A1 (0.47) | KMT2AALDH1A1TDP1POLBMAPT | |
| SCHEMBL5658946 | 0.77 | KMT2A (0.50) | KMT2AALDH1A1TDP1POLBMAPT | |
| SCHEMBL5628029 | 0.76 | L3MBTL1 (0.55) | KMT2AALDH1A1TDP1POLBMAPT | |
| SCHEMBL5644923 | 0.76 | ALDH1A1 (0.51) | KMT2AALDH1A1TDP1POLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7423034-B2 | Benzothiazine and benzothiadiazine compounds | LES LABORATOIRES SERVIER (FR) | 2008-09-09 | — | — | US | disclosed |
| US-20070249594-A1 | Benzothiazine and benzothiadiazine compounds | DESOS PATRICE | 2007-10-25 | — | — | US | disclosed |
| US-7262189-B2 | Benzothiazine and benzothiadiazine derivatives, method for preparing same and pharmaceutical compositions containing same | LES LABORATOIRES SERVER (FR) | 2007-08-28 | — | — | US | disclosed |
| US-7253161-B2 | Benzothiazine and benzothiadiazine derivatives method for preparing same and pharmaceutical compositions containing same | LES LABORATOIRES SERVIER (FR) | 2007-08-07 | — | — | US | disclosed |
| US-7253163-B2 | Benzothiazine and benzothiadiazine compounds | LES LABORATOIRES SERVIER (FR) | 2007-08-07 | — | — | US | disclosed |
| US-7253162-B2 | Benzothiazine and benzothiadiazine compounds | LES LABORATOIRES SERVIER (FR) | 2007-08-07 | — | — | US | disclosed |
| EP-1486503-B1 | Derivatives of benzothiazine and benzothiadiazine, procedure for their preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2006-11-02 | — | — | EP | disclosed |
| US-20050124606-A1 | Novel benzothiazine and benzothiadiazine derivatives method for preparing same and pharmaceutical compositions containing same | LES LABORATOIRES SERVIER (FR) | 2005-06-09 | — | — | US | disclosed |
| US-20050065146-A1 | Novel benzothiazine and benzothiadiazine derivatives, method for preparing same and pharmaceutical compositions containing same | LES LABORATOIRES SERVIER (FR) | 2005-03-24 | — | — | US | disclosed |
| US-20040254371-A1 | New benzothiazine and benzothiadiazine compounds | LES LABORATOIRES SERVIER (FR) | 2004-12-16 | — | — | US | disclosed |
| US-20040254161-A1 | New benzothiazine and benzothiadiazine compounds | LES LABORATOIRES SERVIER (FR) | 2004-12-16 | — | — | US | disclosed |
| EP-1486503-A1 | Derivatives of benzothiazine and benzothiadiazine, procedure for their preparation and pharmaceutical compositions containing them | Les Laboratoires Servier (FR) | 2004-12-15 | — | — | EP | disclosed |
| EP-1486502-A1 | Derivatives of benzothiazine and benzothiadiazine, procedure for their preparation and pharmaceutical compositions containing them | LES LABORATOIRES SERVIER (FR) | 2004-12-15 | — | — | EP | disclosed |
| US-6635635-B2 | 5,5-dioxo-2,3,3a,4-tetrahydro-1 H-pyrrolo(2,1-c)(1,2,4)-benzothiadiazin-7-ol, for example; nervous system disorders; alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) modulators | LES LABORATOIRES SERVIER (FR) | 2003-10-21 | — | — | US | disclosed |
| US-20020037894-A1 | Benzothiadiazine compounds | ADIR ET COMPAGNIE (FR) | 2002-03-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070249594-A1 | Benzothiazine and benzothiadiazine compounds | GRIA4, GABRA4, GRIK4 | KMT2A 467/4885ALDH1A1 505/4885TDP1 1599/4885 |
| US-20040254371-A1 | New benzothiazine and benzothiadiazine compounds | NR4A1, NR4A3, NR4A2 | KMT2A 583/4885ALDH1A1 1073/4885TDP1 2157/4885 |
| US-20040254161-A1 | New benzothiazine and benzothiadiazine compounds | NR4A1, NR4A3, NR4A2 | KMT2A 396/4885ALDH1A1 775/4885TDP1 1501/4885 |
| US-20020037894-A1 | Benzothiadiazine compounds | HCAR1, GLRA1, HCAR2 | KMT2A 987/4885ALDH1A1 239/4885TDP1 1563/4885 |
| US-20050065146-A1 | Novel benzothiazine and benzothiadiazine derivatives, method for preparing same and pharmaceutical compositions containing same | NR5A2, NR4A3, CBR3 | KMT2A 2006/4885ALDH1A1 2038/4885TDP1 4225/4885 |
| US-20050124606-A1 | Novel benzothiazine and benzothiadiazine derivatives method for preparing same and pharmaceutical compositions containing same | NR4A3, NR5A2, NR4A1 | KMT2A 1039/4885ALDH1A1 2161/4885TDP1 3735/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.