SCHEMBL480991

SCHEMBL480991

O=C(O)c1ccncc1Br

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4C Q9H3R0 17/20 0.59
KDM6B O15054 8/20 0.59
KDM4D Q6B0I6 5/20 0.59
KDM4E B2RXH2 2/20 0.59
KDM4A O75164 2/20 0.59
ALDH1A1 P00352 2/20 0.59
MEN1 O00255 1/20 0.59
MAPT P10636 1/20 0.59
THRB P10828 1/20 0.59
KMT2A Q03164 1/20 0.59
TDP1 Q9NUW8 1/20 0.59
L3MBTL1 Q9Y468 1/20 0.59
CCNC P24863 1/20 0.44
CDK8 P49336 1/20 0.44
KDM5A P29375 1/20 0.43
KDM5B Q9UGL1 1/20 0.43
NAPRT Q6XQN6 1/20 0.43
APP P05067 1/20 0.42
GAA P10253 1/20 0.42
HCAR3 P49019 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29920601 1.00 KDM4C (0.59) KDM4CKDM6BKDM4DKDM4EKDM4A
Hydrochloric Acid SCHEMBL2892062 0.98 KDM4C (0.57) KDM4CKDM6BKDM4DKDM4EKDM4A
SCHEMBL933359 0.83 KDM4C (0.53) KDM4CKDM6BKDM4DKDM4EKDM4A
SCHEMBL25207609 0.81 CCNC (0.43) KDM4CKDM6BKDM4DKDM4EKDM4A
SCHEMBL31407215 0.81 CCNC (0.43) KDM4CKDM6BKDM4DKDM4EKDM4A
SCHEMBL30694754 0.81 TDP1 (0.55) KDM4CKDM6BKDM4DKDM4EKDM4A
SCHEMBL5700120 0.81 TDP1 (0.55) KDM4CKDM6BKDM4DKDM4EKDM4A
SCHEMBL30694749 0.81 TDP1 (0.55) KDM4CKDM6BKDM4DKDM4EKDM4A
SCHEMBL5208270 0.81 CCNC (0.43) KDM4CKDM6BKDM4DKDM4EKDM4A
SCHEMBL782625 0.81 CCNC (0.43) KDM4CKDM6BKDM4DKDM4EKDM4A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 458 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109851551-B Method for synthesizing 3-bromoisonicotinic acid intermediate 大连金点生物科技有限公司 2022-05-20 CN claimed
CN-109212051-B Gas chromatography-mass spectrometry combined method for determining nine trace amounts of halogenated nicotinic acid in drinking water 丁立平 2021-11-19 CN claimed
CN-113444084-A Anti-tumor compound and preparation and application thereof 东南大学 2021-09-28 CN claimed
CN-111018775-A High-yield synthesis method of 3-amino methyl isonicotinate 苏州诚和医药化学有限公司 2020-04-17 CN claimed
CN-109851551-A A method of synthesis 3- bromine isonicotinic acid intermediate 大连金点生物科技有限公司 2019-06-07 CN claimed
CN-109212051-A The gas chromatography-mass spectrometry of nine kinds of halogenated niacin of trace in a kind of measurement drinking water 丁立平 2019-01-15 CN claimed
US-4968803-A FLUORINE AS OXIDANT ALLIED-SIGNAL INC. (US) 1990-11-06 US claimed
EP-4713319-A1 SMALL MOLECULE INHIBITORS OF UBIQUITIN SPECIFIC PROTEASE 1 (USP1) AND USES THEREOF Insilico Medicine IP Limited (HK) 2026-03-25 EP disclosed
US-20260049074-A1 THIADIAZOLYL DERIVATIVES IDEAYA BIOSCIENCES, INC. (US) 2026-02-19 US disclosed
US-12534456-B2 Heterocyclyl pyridines as novel fungicides BAYER AKTIENGESELLSCHAFT (DE) 2026-01-27 US disclosed
US-12509454-B2 Thiadiazolyl derivatives IDEAYA BIOSCIENCES, INC. (US) 2025-12-30 US disclosed
US-20250325552-A1 SUBSTITUTED THIADIAZOLYL DERIVATIVES AS DNA POLYMERASE THETA INHIBITORS IDEAYA BIOSCIENCES INC (US) 2025-10-23 US disclosed
US-12398120-B2 Substituted hydantoinamides as ADAMTS7 antagonists BAYER AKTIENGESELLSCHAFT (DE) 2025-08-26 US disclosed
CN-1085219-A New herbicides RHONE POULENC AGRICULTURE (GB) 1994-04-13 CN disclosed
EP-0588357-A1 Isoxazoles derivatives and their use as herbicides RHONE POULENC AGRICULTURE LTD. (GB) 1994-03-23 EP disclosed
US-5294610-A Staphylococcus; side effect reduction MERCK & CO. INC. (US) 1994-03-15 US disclosed
US-4968803-A FLUORINE AS OXIDANT ALLIED-SIGNAL INC. (US) 1990-11-06 US disclosed
US-4046768-A 1-Thiazolyl-5-pyridylcarbonyloxyimidazolidinones VELSICOL CHEMICAL CORPORATION (US) 1977-09-06 US disclosed
US-4045446-A 1-Benzothiazolyl-5-pyridylcarbonyloxyimidazolidinones VELSICOL CHEMICAL CORPORATION (US) 1977-08-30 US disclosed
US-4033753-A HERICIDES VELSICOL CHEMICAL CORPORATION (US) 1977-07-05 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260049074-A1 THIADIAZOLYL DERIVATIVES POLH, POLM, POLD1 KDM4C 4047/4885KDM6B 4083/4885KDM4D 4468/4885
US-20250325552-A1 SUBSTITUTED THIADIAZOLYL DERIVATIVES AS DNA POLYMERASE THETA INHIBITORS POLQ, POLK, POLH KDM4C 3805/4885KDM6B 3846/4885KDM4D 4170/4885
US-12398120-B2 Substituted hydantoinamides as ADAMTS7 antagonists ADAMTS7, MMP7, ADAM17 KDM4C 1947/4885KDM6B 1417/4885KDM4D 2274/4885
US-12534456-B2 Heterocyclyl pyridines as novel fungicides CBR1, CBR3, NOX1 KDM4C 284/4885KDM6B 277/4885KDM4D 1352/4885
US-12509454-B2 Thiadiazolyl derivatives POLD1, POLQ, DNA2 KDM4C 4128/4885KDM6B 4265/4885KDM4D 3145/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.