SCHEMBL481254

SCHEMBL481254

O=C1CCC(=O)N1c1ccc(S(=O)(=O)O)cc1

nearest known ligand 0.67

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
CA12 O43570 2/20 0.67
CA1 P00915 2/20 0.67
CA9 Q16790 2/20 0.67
CA2 P00918 1/20 0.67
LMNA P02545 3/20 0.64
GAA P10253 2/20 0.51
ALDH1A1 P00352 2/20 0.51
KMT2A Q03164 2/20 0.50
POLB P06746 2/20 0.48
GLA P06280 1/20 0.47
TSHR P16473 1/20 0.43
NT5E P21589 1/20 0.43
HSD17B10 Q99714 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12793541 0.83 CA12 (0.71) CA12CA1CA9CA2LMNA
SCHEMBL20118964 0.80 CA1 (1.00) CA12CA1CA9CA2LMNA
SCHEMBL11478927 0.80 CA12 (0.67) CA12CA1CA9CA2LMNA
Sulfuric Acid SCHEMBL1535692 0.78 CA12 (0.54) CA12CA1CA9CA2LMNA
SCHEMBL11022463 0.78 AR (0.44) CA12CA1CA9CA2LMNA
SCHEMBL1830817 0.78 MGLL (0.62) LMNAALDH1A1TSHRNT5E
SCHEMBL11028524 0.77 CA2 (0.43) CA12CA1CA9CA2LMNA
SCHEMBL4837136 0.76 MGLL (0.60) LMNAALDH1A1TSHRNT5E
SCHEMBL18181415 0.76 GAA (0.52) CA12CA1CA9CA2LMNA
SCHEMBL12793823 0.76 ALDH1A1 (0.68) CA12CA1CA9CA2LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7723425-B2 Pigment compositions with modified ATRP copolymer dispersants CIBA SPECIALTY CHEMICALS CORPORATION (US) 2010-05-25 US claimed
US-20210139423-A1 CHEMICAL MODULATORS OF STORE-OPERATED CALCIUM CHANNELS AND THEIR THERAPEUTIC APPLICATIONS THE TEXAS A&M UNIVERSITY SYSTEM 2021-05-13 US disclosed
US-20190092723-A1 CHEMICAL MODULATORS OF STORE-OPERATED CALCIUM CHANNELS AND THEIR THERAPEUTIC APPLICATIONS THE TEXAS A&M UNIVERSITY SYSTEM (US) 2019-03-28 US disclosed
EP-1465935-B1 PIGMENT COMPOSITIONS WITH MODIFIED ATRP COPOLYMER DISPERSANTS BASF SE (DE) 2016-09-07 EP disclosed
EP-2411437-B9 COMPOSITION COMPRISING STABLE POLYOL MIXTURES BYK CHEMIE GMBH (DE) 2013-07-31 EP disclosed
EP-2411437-B1 COMPOSITION COMPRISING STABLE POLYOL MIXTURES BYK CHEMIE GMBH (DE) 2013-05-08 EP disclosed
EP-1611197-B1 LIGHT STABILISING POLYMER DISPERSANTS IN PIGMENT DISPERSIONS BASF SE (DE) 2012-03-21 EP disclosed
US-20120029104-A1 COMPOSITION COMPRISING STABLE POLYOL MIXTURES BYK-CHEMIE GMBH (DE) 2012-02-02 US disclosed
EP-2411437-A2 COMPOSITION COMPRISING STABLE POLYOL MIXTURES BYK-Chemie GmbH (DE) 2012-02-01 EP disclosed
US-20120003583-A1 ACTINIC RAY-SENSITIVE OR RADIATION-SENSITIVE RESIN COMPOSITION, AND RESIST FILM AND PATTERN FORMING METHOD USING THE COMPOSITION FUJIFILM CORPORATION (JP) 2012-01-05 US disclosed
US-20120003583-A1 ACTINIC RAY-SENSITIVE OR RADIATION-SENSITIVE RESIN COMPOSITION, AND RESIST FILM AND PATTERN FORMING METHOD USING THE COMPOSITION FUJIFILM CORPORATION (JP) 2012-01-05 US disclosed
WO-2010108672-A2 COMPOSITION COMPRISING STABLE POLYOL MIXTURES BYK-CHEMIE GMBH (DE) 2010-09-30 WO disclosed
US-20060229407-A1 Light stabilising polymer dispersants in pigment dispersions CIBA SPECIALTY CHEMICALS CORP. 2006-10-12 US disclosed
US-20060160940-A1 Process for intercalating natural or szynthetic clays with block or comb copolymers CIBA SPECIALTY CHEMICALS CORP. 2006-07-20 US disclosed
US-6849679-B2 Pigment compositions with modified block copolymer dispersants CIBA SPECIALTY CHEMICALS CORPORATION (US) 2005-02-01 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210139423-A1 CHEMICAL MODULATORS OF STORE-OPERATED CALCIUM CHANNELS AND THEIR THERAPEUTIC APPLICATIONS ORAI1, SARAF, CACNA1C CA12 2684/4885CA1 399/4885CA9 3130/4885
US-20190092723-A1 CHEMICAL MODULATORS OF STORE-OPERATED CALCIUM CHANNELS AND THEIR THERAPEUTIC APPLICATIONS ORAI1, SARAF, CACNA1C CA12 2684/4885CA1 399/4885CA9 3130/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.