Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 4/20 | 0.47 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.47 |
| ▸ | DRD3 | P35462 | 5/20 | 0.37 |
| ▸ | DRD2 | P14416 | 4/20 | 0.37 |
| ▸ | DRD4 | P21917 | 3/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 2/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | DRD1 | P21728 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23207727 | 0.76 | OPRM1 (0.56) | OPRM1OPRL1DRD2SLC6A2KDM4E | |
| SCHEMBL2592119 | 0.65 | CHRM2 (0.48) | OPRM1OPRL1CHRM1 | |
| SCHEMBL4813101 | 0.65 | OPRM1 (0.41) | OPRM1OPRL1SLC6A2SLC6A4 | |
| Hydrochloric Acid SCHEMBL2588318 | 0.64 | OPRM1 (0.40) | OPRM1OPRL1SLC6A2SLC6A4 | |
| SCHEMBL4667127 | 0.62 | LMNA (0.40) | OPRM1DRD3SLC6A2OPRD1ALDH1A1 | |
| SCHEMBL11051916 | 0.62 | LMNA (0.40) | OPRM1DRD3SLC6A2OPRD1ALDH1A1 | |
| SCHEMBL10361267 | 0.62 | SLC6A2 (0.43) | OPRM1DRD3SLC6A2OPRD1ALDH1A1 | |
| SCHEMBL28079957 | 0.61 | OPRM1 (0.36) | OPRM1OPRL1OPRD1 | |
| SCHEMBL3301280 | 0.61 | SLC6A2 (0.38) | OPRM1DRD3SLC6A2OPRD1CHRM1 | |
| SCHEMBL4820734 | 0.60 | OPRM1 (0.41) | OPRM1DRD3SLC6A2OPRD1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7459556-B2 | Process for preparing substituted 8-azabicyclo[3.2.1]octan-3-ols | SCHERING-PLOUGH LTD. (CH) | 2008-12-02 | — | — | US | disclosed |
| EP-1791838-A2 | PROCESS FOR PREPARING SUBSTITUTED 8-AZABICYCLO[3.2.1] OCTAN-3-OLS | Schering-Plough Ltd. (CH) | 2007-06-06 | — | — | EP | disclosed |
| WO-2006031788-A2 | PROCESS FOR PREPARING SUBSTITUTED 8-AZABICYCLO[3.2.1] OCTAN-3-OLS | SCHERING-PLOUGH LTD. (CH) | 2006-03-23 | — | — | WO | disclosed |
| US-20060058343-A1 | Process for preparing substituted 8-azabicyclo[3.2.1]octan-3-ols | SCHERING-PLOUGH LTD. (CH) | 2006-03-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060058343-A1 | Process for preparing substituted 8-azabicyclo[3.2.1]octan-3-ols | ODC1, CYP2C8, OR10J3 | OPRM1 223/4885OPRL1 632/4885DRD3 31/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.