Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.62 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31019312 | 0.88 | GAA (0.54) | ALDH1A1SMN1; SMN2GAAPKMMAPT | |
| SCHEMBL673608 | 0.86 | ALDH1A1 (0.64) | ALDH1A1SMN1; SMN2GAAPKMMAPT | |
| SCHEMBL13979120 | 0.85 | ALDH1A1 (0.63) | ALDH1A1SMN1; SMN2GAAPKMMAPT | |
| SCHEMBL6277688 | 0.81 | SMN1; SMN2 (0.56) | ALDH1A1SMN1; SMN2GAAPKMMAPT | |
| Hydrochloric Acid SCHEMBL8841049 | 0.81 | SMN1; SMN2 (0.56) | ALDH1A1SMN1; SMN2GAAPKMMAPT | |
| SCHEMBL31019313 | 0.81 | ALDH1A1 (0.55) | ALDH1A1SMN1; SMN2GAAPKMMAPT | |
| SCHEMBL10039350 | 0.80 | ALDH1A1 (0.56) | ALDH1A1SMN1; SMN2GAAPKMMAPT | |
| SCHEMBL671879 | 0.78 | ALDH1A1 (0.55) | ALDH1A1SMN1; SMN2GAAPKMMAPT | |
| SCHEMBL15023508 | 0.74 | ALDH1A1 (0.63) | ALDH1A1SMN1; SMN2PKMMAPTLMNA | |
| SCHEMBL670769 | 0.74 | ALDH1A1 (0.51) | ALDH1A1SMN1; SMN2GAAPKMMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220017432-A1 | CONJUGATES DERIVED FROM NON-STEROIDAL ANTI-INFLAMMATORY DRUGS AND METHODS OF USE THEREOF IN IMAGING | Reiley Pharmaceuticals, Inc. | 2022-01-20 | — | — | US | disclosed |
| US-20190169084-A1 | CONJUGATES DERIVED FROM NON-STEROIDAL ANTI-INFLAMMATORY DRUGS AND METHODS OF USE THEREOF IN IMAGING | Reiley Pharmaceuticals, Inc. | 2019-06-06 | — | — | US | disclosed |
| US-20180162784-A1 | CONJUGATES DERIVED FROM NON-STEROIDAL ANTI-INFLAMMATORY DRUGS AND METHODS OF USE THEREOF IN IMAGING | Reiley Pharmaceuticals, Inc. | 2018-06-14 | — | — | US | disclosed |
| US-9850183-B2 | Conjugates derived from non-steroidal anti-inflammatory drugs and methods of use thereof in imaging | Reiley Pharmaceuticals, Inc. (US) | 2017-12-26 | — | — | US | disclosed |
| US-20150374858-A1 | CONJUGATES DERIVED FROM NON-STEROIDAL ANTI-INFLAMMATORY DRUGS AND METHODS OF USE THEREOF IN IMAGING | Reiley Pharmaceuticals, Inc. | 2015-12-31 | — | — | US | disclosed |
| WO-2015200187-A1 | CONJUGATES DERIVED FROM NON-STEROIDAL ANTI-INFLAMMATORY DRUGS AND METHODS OF USE THEREOF IN IMAGING | Reiley Pharmaceuticals, Inc. (US) | 2015-12-30 | — | — | WO | disclosed |
| US-7378079-B2 | Agents for imaging and diagnostic methods using them | NST NEUROSURVIVAL TECHNOLOGIES LTD. (IL) | 2008-05-27 | — | — | US | disclosed |
| US-7378079-B2 | Agents for imaging and diagnostic methods using them | NST NEUROSURVIVAL TECHNOLOGIES LTD. (IL) | 2008-05-27 | — | — | US | disclosed |
| US-7378079-B2 | Agents for imaging and diagnostic methods using them | NST NEUROSURVIVAL TECHNOLOGIES LTD. (IL) | 2008-05-27 | — | — | US | disclosed |
| US-20050276750-A1 | Agents for imaging and diagnostic methods using them | APOSENSE LTD. (IL) | 2005-12-15 | — | — | US | disclosed |
| EP-1546092-A2 | AGENTS FOR IMAGING AND DIAGNOSTIC METHODS USING THEM | Nst Neurosurvival Technologies Ltd. (IL) | 2005-06-29 | — | — | EP | disclosed |
| WO-2003101948-A2 | AGENTS FOR IMAGING AND DIAGNOSTIC METHODS USING THEM | NST NEUROSURVIVAL TECHNOLOGIES LTD. (IL) | 2003-12-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180162784-A1 | CONJUGATES DERIVED FROM NON-STEROIDAL ANTI-INFLAMMATORY DRUGS AND METHODS OF USE THEREOF IN IMAGING | PTGES3, PTGES, HPGDS | ALDH1A1 626/4885SMN1; SMN2 4033/4885GAA 3332/4885 |
| US-20220017432-A1 | CONJUGATES DERIVED FROM NON-STEROIDAL ANTI-INFLAMMATORY DRUGS AND METHODS OF USE THEREOF IN IMAGING | PTGES3, PTGES, HPGDS | ALDH1A1 626/4885SMN1; SMN2 4033/4885GAA 3332/4885 |
| US-20050276750-A1 | Agents for imaging and diagnostic methods using them | ANXA4, ANXA3, NME4 | ALDH1A1 4325/4885SMN1; SMN2 2097/4885GAA 1769/4885 |
| US-20150374858-A1 | CONJUGATES DERIVED FROM NON-STEROIDAL ANTI-INFLAMMATORY DRUGS AND METHODS OF USE THEREOF IN IMAGING | PTGES3, PTGES, HPGDS | ALDH1A1 626/4885SMN1; SMN2 4033/4885GAA 3332/4885 |
| US-20190169084-A1 | CONJUGATES DERIVED FROM NON-STEROIDAL ANTI-INFLAMMATORY DRUGS AND METHODS OF USE THEREOF IN IMAGING | PTGES3, PTGES, HPGDS | ALDH1A1 626/4885SMN1; SMN2 4033/4885GAA 3332/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.