Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | PTPRB | P23467 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | CDC7 | O00311 | 1/20 | 0.34 |
| ▸ | PLK4 | O00444 | 1/20 | 0.34 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4814991 | 0.88 | MAPT (0.38) | LMNAKMT2ATSHRMAPTHTT | |
| SCHEMBL6544947 | 0.86 | HSD17B10 (0.44) | LMNAKMT2ATSHRMAPTHTT | |
| SCHEMBL2921682 | 0.72 | PDK1 (0.58) | SMN1; SMN2ALDH1A1HPGDGAAL3MBTL1 | |
| SCHEMBL15765839 | 0.72 | KMT2A (0.68) | LMNAKMT2ATSHRMAPTHTT | |
| SCHEMBL10892245 | 0.72 | RAPGEF4 (0.52) | LMNAKMT2ATSHRMAPTHTT | |
| SCHEMBL4351761 | 0.69 | PDE4A (0.44) | LMNAKMT2ATSHRMAPTHTT | |
| SCHEMBL22430515 | 0.68 | HSD17B10 (0.51) | LMNAKMT2ATSHRMAPTHTT | |
| SCHEMBL7264596 | 0.68 | KMT2A (0.54) | LMNAKMT2ATSHRMAPTHTT | |
| SCHEMBL8130619 | 0.68 | ALDH1A1 (0.67) | LMNAKMT2ATSHRMAPTSMN1; SMN2 | |
| SCHEMBL6243369 | 0.68 | ALDH1A1 (0.56) | LMNATSHRMAPTSMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7390925-B2 | Oxime-containing acyl guanidines as beta-secretase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-06-24 | — | — | US | claimed |
| US-20070232581-A1 | Oxime-Containing Acyl Guanidines as Beta-Secretase Inhibitors | BRISTOL-MYERS SQUIBB COMPANY | 2007-10-04 | — | — | US | claimed |
| US-7390925-B2 | Oxime-containing acyl guanidines as beta-secretase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-06-24 | — | — | US | disclosed |
| US-20070232581-A1 | Oxime-Containing Acyl Guanidines as Beta-Secretase Inhibitors | BRISTOL-MYERS SQUIBB COMPANY | 2007-10-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070232581-A1 | Oxime-Containing Acyl Guanidines as Beta-Secretase Inhibitors | BACE1, APP, BACE2 | LMNA 1383/4885KMT2A 2775/4885TSHR 3068/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.