Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 10/20 | 0.42 |
| ▸ | PPARA | Q07869 | 7/20 | 0.42 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.35 |
| ▸ | PPARD | Q03181 | 2/20 | 0.35 |
| ▸ | CACNA1B | Q00975 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4822987 | 0.93 | PPARG (0.49) | PPARGPPARAPPARD | |
| SCHEMBL1862230 | 0.93 | PPARG (0.49) | PPARGPPARAPPARD | |
| SCHEMBL4817522 | 0.92 | PPARG (0.49) | PPARGPPARAPPARD | |
| SCHEMBL4825027 | 0.91 | SIRT1 (0.36) | PPARGPPARASIRT1CACNA1BLMNA | |
| SCHEMBL1865976 | 0.91 | PPARG (0.41) | PPARGPPARASIRT1LMNATP53 | |
| SCHEMBL4827271 | 0.90 | PPARG (0.34) | PPARGPPARAPPARDLMNATP53 | |
| SCHEMBL1860645 | 0.89 | PPARG (0.46) | PPARGPPARAPPARD | |
| SCHEMBL4822586 | 0.89 | PPARG (0.41) | PPARGPPARASIRT1CACNA1BTP53 | |
| SCHEMBL1870590 | 0.86 | PPARG (0.39) | PPARGPPARASIRT1PPARDCACNA1B | |
| SCHEMBL4825231 | 0.86 | PPARG (0.39) | PPARGPPARASIRT1PPARDCACNA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7365064-B2 | Benzoxazine and benzothiazine derivatives and pharmaceutical compositions containing them | DR. REDDY'S LABORATORIES LIMITED (IN) | 2008-04-29 | — | — | US | disclosed |
| US-20050113368-A1 | Benzoxazine and benzothiazine derivatives and pharmaceutical compositions containing them | DR. REDDY'S LABORATORIES LIMITED (IN) | 2005-05-26 | — | — | US | disclosed |
| EP-1436268-A1 | BENZOXAZINE AND BENZOTHIAZINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Dr. Reddy's Laboratories Ltd. (IN) | 2004-07-14 | — | — | EP | disclosed |
| WO-2003033481-A1 | BENZOXAZINE AND BENZOTHIAZINE DERIVATIVES AND PARMACEUTICAL COMPOSITIONS CONTAINING THEM | DR. REDDY'S LABORATORIES LTD. (IN) | 2003-04-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050113368-A1 | Benzoxazine and benzothiazine derivatives and pharmaceutical compositions containing them | CYP3A5, HBZ, CYP4Z1 | PPARG 86/4885PPARA 113/4885SIRT1 2419/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.