Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.60 |
| ▸ | NCF1 | P14598 | 1/20 | 0.48 |
| ▸ | HTR1A | P08908 | 2/20 | 0.47 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.47 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | FERMT2 | Q96AC1 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4870247 | 0.89 | LOXL2 (0.56) | LOXL2NCF1HTR1AADRA1DADRA1A | |
| SCHEMBL5541655 | 0.87 | LOXL2 (0.55) | LOXL2NCF1HTR1AADRA1DADRA1A | |
| SCHEMBL5537149 | 0.86 | CYP19A1 (0.54) | LOXL2NCF1HTR1AADRA1DADRA1A | |
| SCHEMBL16289396 | 0.85 | LOXL2 (0.53) | LOXL2NCF1HTR1AADRA1DADRA1A | |
| SCHEMBL16288899 | 0.85 | LOXL2 (0.53) | LOXL2NCF1HTR1AADRA1DADRA1A | |
| SCHEMBL5542236 | 0.85 | LOXL2 (0.53) | LOXL2NCF1HTR1AADRA1DADRA1A | |
| SCHEMBL7767284 | 0.85 | LOXL2 (0.53) | LOXL2NCF1HTR1AADRA1DADRA1A | |
| SCHEMBL3817375 | 0.83 | LOXL2 (0.64) | LOXL2NCF1HTR1AADRA1DADRA1A | |
| SCHEMBL2333461 | 0.82 | LOXL2 (0.62) | LOXL2NCF1HTR1AADRA1DADRA1A | |
| SCHEMBL2331919 | 0.82 | LOXL2 (0.62) | LOXL2NCF1HTR1AADRA1DADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 124 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7365174-B2 | Azalide and azalactam derivatives and method for producing the same | MEIJI SEIKA KAISHA, LTD. (JP) | 2008-04-29 | — | — | US | claimed |
| EP-1642901-B1 | Novel erythromycin derivatives | PFIZER PROD INC (US) | 2007-10-31 | — | — | EP | claimed |
| US-20070042974-A1 | Nozel azalide and azalactam derivatives and method for producing the same | MEIJI SEIKA KAISHA, LTD. (JP) | 2007-02-22 | — | — | US | claimed |
| EP-1661904-A1 | NOVEL AZALIDE AND AZALACTAM DERIVATIVES AND PROCESS FOR THE PRODUCTION OF THE SAME | MEIJI SEIKA KAISHA LTD. (JP) | 2006-05-31 | — | — | EP | claimed |
| EP-1642901-A1 | Novel erythromycin derivatives | Pfizer Products Inc. (US) | 2006-04-05 | — | — | EP | claimed |
| US-20050209446-A1 | Novel 15-membered cyclic azalide, novel 16-membered cyclic diazalide derivative, and process for producing these | MEIJI SEIKA KAISHA LTD. (JP) | 2005-09-22 | — | — | US | claimed |
| CN-1639181-A | Novel 15-membered cyclic azalide, novel 16-membered cyclic diazalide derivative, and process for producing these | MEIJI SEIKA KAISHA (JP) | 2005-07-13 | — | — | CN | claimed |
| US-6825171-B2 | MACROLIDE ANTIBIOTIC USEFUL IN THE TREATMENT OF A BROAD SPRECTRUM OF BACTERIAL INFECTIONS AND PROTOZOA INFECTIONS | PFIZER, INC. | 2004-11-30 | — | — | US | claimed |
| EP-1479687-A1 | NOVEL 15-MEMBERED CYCLIC AZALIDE, NOVEL 16-MEMBERED CYCLIC DIAZALIDE DERIVATIVE, AND PROCESS FOR PRODUCING THESE | MEIJI SEIKA KAISHA LTD. (JP) | 2004-11-24 | — | — | EP | claimed |
| US-20040067897-A1 | Novel erythromycin derivatives | PFIZER INC. | 2004-04-08 | — | — | US | claimed |
| WO-2000010985-A1 | ENANTIOSELECTIVE CHIRAL SULPHIDE CATALYSTS AND A METHOD FOR THE MANUFACTURE THEREOF | NESTE CHEMICALS OY (FI) | 2000-03-02 | — | — | WO | claimed |
| WO-1999062920-A1 | TRICYCLIC 3-KETO DERIVATIVES OF 6-O-METHYLERYTHROMYCIN | PFIZER PRODUCTS INC. (US) | 1999-12-09 | — | — | WO | claimed |
| EP-0952157-A1 | 9A, 11B-Dehydro derivatives of 9-oxime-3-keto-6-0-methylerythromycin | Pfizer Products Inc. (US) | 1999-10-27 | — | — | EP | claimed |
| CN-1224426-A | 3-descladinose-2, 3-anhydroerythromycin derivatives | ABBOTT LAB (US) | 1999-07-28 | — | — | CN | claimed |
| WO-1999035157-A1 | NOVEL ERYTHROMYCIN DERIVATIVES | PFIZER PRODUCTS INC. (US) | 1999-07-15 | — | — | WO | claimed |
| EP-0922050-A1 | 3-DESCLADINOSE-2,3-ANHYDROERYTHROMYCIN DERIVATIVES | ABBOTT LABORATORIES (US) | 1999-06-16 | — | — | EP | claimed |
| WO-1999021865-A1 | TRICYCLIC ERYTHROMYCIN DERIVATIVES | PFIZER PRODUCTS INC. (US) | 1999-05-06 | — | — | WO | claimed |
| US-5750510-A | ANTIBIOTICS | ABBOTT LABORATORIES (US) | 1998-05-12 | — | — | US | claimed |
| WO-1997042205-A1 | 3-DESCLADINOSE-2,3-ANHYDROERYTHROMYCIN DERIVATIVES | ABBOTT LABORATORIES (US) | 1997-11-13 | — | — | WO | claimed |
| EP-0008962-B1 | 4-(4-QUINOLYLPROPYL)PIPERIDINE DERIVATIVES AND PHARMACEUTICALS CONTAINING THEM | PHARMUKA LABORATOIRES (FR) | 1983-02-09 | — | — | EP | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050209446-A1 | Novel 15-membered cyclic azalide, novel 16-membered cyclic diazalide derivative, and process for producing these | PRMT9, DHRS9, MRPL9 | LOXL2 4122/4885NCF1 1690/4885HTR1A 4086/4885 |
| US-20070042974-A1 | Nozel azalide and azalactam derivatives and method for producing the same | BCL6, NR4A1, NR4A2 | LOXL2 4109/4885NCF1 85/4885HTR1A 2932/4885 |
| US-20040067897-A1 | Novel erythromycin derivatives | GIPR, MLNR, PGC | LOXL2 4313/4885NCF1 3382/4885HTR1A 1880/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.