Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 11/20 | 0.50 |
| ▸ | MEN1 | O00255 | 4/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | RECQL | P46063 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.47 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.47 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | GSK3A | P49840 | 3/20 | 0.44 |
| ▸ | GSK3B | P49841 | 3/20 | 0.44 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.44 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.44 |
| ▸ | AHR | P35869 | 1/20 | 0.44 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2209657 | 0.94 | MEN1 (0.56) | MAPTMEN1KMT2AALDH1A1L3MBTL1 | |
| SCHEMBL481932 | 0.89 | MAPT (0.47) | MAPTMEN1KMT2AALDH1A1L3MBTL1 | |
| SCHEMBL482356 | 0.77 | ALDH1A1 (0.53) | MAPTMEN1KMT2AALDH1A1L3MBTL1 | |
| SCHEMBL10711270 | 0.73 | L3MBTL1 (0.67) | MAPTMEN1KMT2AALDH1A1L3MBTL1 | |
| SCHEMBL481445 | 0.73 | KMT2A (0.65) | MAPTMEN1KMT2AALDH1A1L3MBTL1 | |
| SCHEMBL27539926 | 0.72 | MAPK1 (0.64) | MAPTMEN1KMT2AALDH1A1L3MBTL1 | |
| SCHEMBL31455503 | 0.70 | ABCG2 (0.38) | MAPTMEN1KMT2AALDH1A1L3MBTL1 | |
| SCHEMBL31455712 | 0.68 | TSHR (0.42) | MAPTMEN1KMT2AALDH1A1L3MBTL1 | |
| SCHEMBL31455452 | 0.68 | ABCG2 (0.39) | MAPTMEN1KMT2AALDH1A1RAB9A | |
| SCHEMBL2464563 | 0.68 | MEN1 (1.00) | MAPTMEN1KMT2AALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2078016-B1 | HETEROARYL COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH | SIGNAL PHARM LLC (US) | 2012-02-01 | — | — | EP | disclosed |