Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 4/20 | 0.56 |
| ▸ | TDP2 | O95551 | 2/20 | 0.47 |
| ▸ | PARP1 | P09874 | 1/20 | 0.43 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.43 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.43 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.43 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.43 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.43 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 4/20 | 0.41 |
| ▸ | HTR2C | P28335 | 4/20 | 0.41 |
| ▸ | HTR2B | P41595 | 4/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.37 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2310562 | 0.87 | PNMT (0.56) | PNMTTDP2PARP1PARP10CHRNB2 | |
| SCHEMBL29835145 | 0.87 | PNMT (0.56) | PNMTTDP2PARP1PARP10CHRNB2 | |
| Hydrochloric Acid SCHEMBL1647036 | 0.85 | PNMT (0.54) | PNMTTDP2PARP1PARP10CHRNB2 | |
| Bromide SCHEMBL2310632 | 0.85 | PNMT (0.54) | PNMTTDP2PARP1PARP10CHRNB2 | |
| Hydrochloric Acid SCHEMBL29627981 | 0.85 | PNMT (0.54) | PNMTTDP2PARP1PARP10CHRNB2 | |
| Bromide SCHEMBL2310627 | 0.83 | PNMT (0.53) | PNMTTDP2PARP1PARP10CHRNB2 | |
| SCHEMBL329770 | 0.76 | ASIC3 (0.69) | PNMTPARP1PARP10ASIC3HTR2A | |
| SCHEMBL29808272 | 0.76 | ASIC3 (0.60) | PNMTPARP1PARP10ASIC3HTR2A | |
| SCHEMBL183621 | 0.76 | ASIC3 (0.60) | PNMTPARP1PARP10ASIC3HTR2A | |
| Hydrochloric Acid SCHEMBL1000239 | 0.75 | ASIC3 (0.59) | PNMTPARP1PARP10ASIC3HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1606280-A4 | TETRAHYDROPYRANYL CYCLOPENTYL HETEROCYLIC AMIDE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | MERCK & CO INC (US) | 2008-12-24 | — | — | EP | disclosed |
| US-7393844-B2 | Tetrahydropyranyl cyclopentyl heterocyclic amide modulators of chemokine receptor activity | MERCK & CO., INC. (US) | 2008-07-01 | — | — | US | disclosed |
| US-7393844-B2 | Tetrahydropyranyl cyclopentyl heterocyclic amide modulators of chemokine receptor activity | MERCK & CO., INC. (US) | 2008-07-01 | — | — | US | disclosed |
| US-7393844-B2 | Tetrahydropyranyl cyclopentyl heterocyclic amide modulators of chemokine receptor activity | MERCK & CO., INC. (US) | 2008-07-01 | — | — | US | disclosed |
| US-20060178363-A1 | Tetrahydropyranyl cyclopentyl heterocyclic amide modulators of chemokine receptor activity | MERCK SHARP & DOHME CORP. | 2006-08-10 | — | — | US | disclosed |
| EP-1606280-A2 | TETRAHYDROPYRANYL CYCLOPENTYL HETEROCYLIC AMIDE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | Merck & Co. Inc. (US) | 2005-12-21 | — | — | EP | disclosed |
| WO-2004082616-A2 | TETRAHYDROPYRANYL CYCLOPENTYL HETEROCYLIC AMIDE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | MERCK & CO. INC. (US) | 2004-09-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060178363-A1 | Tetrahydropyranyl cyclopentyl heterocyclic amide modulators of chemokine receptor activity | CCR1, CCR2, CCR5 | PNMT 4295/4885TDP2 3712/4885PARP1 3188/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.