Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 1/20 | 0.60 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.60 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.60 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | ALB | P02768 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | CHRM1 | P11229 | 11/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.51 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.51 |
| ▸ | CDK2 | P24941 | 1/20 | 0.51 |
| ▸ | CCKBR | P32239 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4790341 | 0.82 | GABRA1 (0.54) | MEN1LMNAKMT2ACHRM1ALDH1A1 | |
| SCHEMBL13584771 | 0.76 | MEN1 (0.61) | CNR1NTSR1OPRK1PDE4DMEN1 | |
| SCHEMBL13584770 | 0.76 | MEN1 (0.61) | CNR1NTSR1OPRK1PDE4DMEN1 | |
| Nordazepam SCHEMBL78453 | 0.75 | PDE4D (1.00) | CNR1NTSR1OPRK1PDE4DMEN1 | |
| Nordazepam SCHEMBL29354494 | 0.75 | PDE4D (1.00) | CNR1NTSR1OPRK1PDE4DMEN1 | |
| Nordazepam SCHEMBL31000330 | 0.75 | PDE4D (1.00) | CNR1NTSR1OPRK1PDE4DMEN1 | |
| Nordazepam SCHEMBL8090999 | 0.75 | PDE4D (1.00) | CNR1NTSR1OPRK1PDE4DMEN1 | |
| SCHEMBL10812464 | 0.74 | LMNA (0.74) | CNR1NTSR1OPRK1PDE4DMEN1 | |
| Oxazepam SCHEMBL9614141 | 0.73 | LMNA (1.00) | CNR1NTSR1OPRK1PDE4DMEN1 | |
| Oxazepam SCHEMBL5498881 | 0.73 | LMNA (1.00) | CNR1NTSR1OPRK1PDE4DMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7375101-B2 | Benzodiazepine derivatives, preparation thereof and use thereof | ASTRAZENECA AB (SE) | 2008-05-20 | — | — | US | disclosed |
| US-20050176699-A1 | Benzodiazepine derivatives, preparation thereof and use thereof | ASTRAZENECA AB (SE) | 2005-08-11 | — | — | US | disclosed |
| EP-1458691-A2 | BENZODIAZEPINE DERIVATIVES, PREPARATION THEREOF AND USE THEREOF | AstraZeneca AB (SE) | 2004-09-22 | — | — | EP | disclosed |
| WO-2003051274-A2 | BENZODIAZEPINE DERIVATIVES, PREPARATION THEREOF AND USE THEREOF | ASTRAZENECA AB (SE) | 2003-06-26 | — | — | WO | disclosed |
| WO-2003051275-A2 | BENZODIAZEPINE DERIVATIVES, PREPARATION THEREOF AND USE THEREOF | ASTRAZENECA AB (SE) | 2003-06-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050176699-A1 | Benzodiazepine derivatives, preparation thereof and use thereof | GABRA1, GABRA3, GABRA4 | CNR1 24/4885NTSR1 603/4885OPRK1 9/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.