Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 1/20 | 0.50 |
| ▸ | HTR2B | P41595 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.47 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.47 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.47 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | EDNRB | P24530 | 1/20 | 0.44 |
| ▸ | EDNRA | P25101 | 1/20 | 0.44 |
| ▸ | GPR3 | P46089 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetone SCHEMBL8469766 | 0.91 | POLB (0.55) | HTR7HTR2BPOLBHDAC3HDAC4 | |
| SCHEMBL40599 | 0.87 | GPR3 (0.52) | HTR7HTR2BPOLBHDAC3HDAC4 | |
| SCHEMBL29641604 | 0.87 | GPR3 (0.52) | HTR7HTR2BPOLBHDAC3HDAC4 | |
| SCHEMBL7825562 | 0.81 | HTR7 (0.62) | HTR7HTR2BPOLBKMT2AMEN1 | |
| SCHEMBL26119869 | 0.81 | TTR (0.51) | HTR7HTR2BPOLBKMT2AMAPT | |
| SCHEMBL30571871 | 0.81 | HTR7 (0.62) | HTR7HTR2BPOLBKMT2AMEN1 | |
| SCHEMBL6901219 | 0.78 | CDC25B (0.52) | HTR7HTR2BPOLBNCOR2KMT2A | |
| SCHEMBL30045412 | 0.78 | HTR7 (0.40) | HTR7HTR2BPOLBHDAC3HDAC4 | |
| SCHEMBL3680763 | 0.77 | HTR7 (0.48) | HTR7HTR2BPOLBTSHRMAPT | |
| SCHEMBL3233540 | 0.77 | POLB (0.39) | HTR7HTR2BPOLBHDAC3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7429601-B2 | Esters of hydroxyl-substituted nitrogen heterocycles, processes for the preparation thereof as well as the use thereof as pharmaceutical compositions | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG, (DE) | 2008-09-30 | — | — | US | disclosed |
| US-7094788-B2 | Esters of hydroxyl-substituted nitrogen heterocycles, processes for the preparation thereof as well as the use thereof as pharmaceutical compositions | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2006-08-22 | — | — | US | disclosed |
| US-20060058344-A1 | Esters of hydroxyl-substituted nitrogen heterocycles, processes for the preparation thereof as well as the use thereof as pharmaceutical compositions | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2006-03-16 | — | — | US | disclosed |
| US-20030199545-A1 | New esters of hydroxyl-substituted nitrogen heterocycles, processes for the preparation thereof as well as the use thereof as pharmaceutical compositions | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2003-10-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030199545-A1 | New esters of hydroxyl-substituted nitrogen heterocycles, processes for the preparation thereof as well as the use thereof as pharmaceutical compositions | CYP4B1, CYP3A4, CYP4A11 | HTR7 747/4885HTR2B 359/4885POLB 3606/4885 |
| US-20060058344-A1 | Esters of hydroxyl-substituted nitrogen heterocycles, processes for the preparation thereof as well as the use thereof as pharmaceutical compositions | CYP4B1, CYP2C19, CYP4A11 | HTR7 562/4885HTR2B 200/4885POLB 3227/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.