Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNB2 | O95067 | 2/20 | 0.68 |
| ▸ | CDK1 | P06493 | 2/20 | 0.68 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.68 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.68 |
| ▸ | CDK2 | P24941 | 2/20 | 0.68 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.68 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.68 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.68 |
| ▸ | CCNB3 | Q8WWL7 | 2/20 | 0.68 |
| ▸ | MAOA | P21397 | 16/20 | 0.64 |
| ▸ | DYRK1A | Q13627 | 6/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.64 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.64 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.64 |
| ▸ | HPGD | P15428 | 2/20 | 0.64 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.64 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.64 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2720910 | 0.87 | MAOA (0.61) | CCNB2CDK1CCNB1CCNA2CDK2 | |
| SCHEMBL15236149 | 0.83 | CCNB2 (0.71) | CCNB2CDK1CCNB1CCNA2CDK2 | |
| SCHEMBL177685 | 0.81 | CCNB2 (0.68) | CCNB2CDK1CCNB1CCNA2CDK2 | |
| SCHEMBL16126068 | 0.81 | CCNB2 (0.68) | CCNB2CDK1CCNB1CCNA2CDK2 | |
| SCHEMBL30939928 | 0.81 | CCNB2 (0.68) | CCNB2CDK1CCNB1CCNA2CDK2 | |
| SCHEMBL23150422 | 0.81 | CCNB2 (0.68) | CCNB2CDK1CCNB1CCNA2CDK2 | |
| Hydrochloric Acid SCHEMBL647417 | 0.79 | CCNB2 (0.66) | CCNB2CDK1CCNB1CCNA2CDK2 | |
| Hydrochloric Acid SCHEMBL3769079 | 0.78 | CCNB2 (0.64) | CCNB2CDK1CCNB1CCNA2CDK2 | |
| Harmine SCHEMBL9481427 | 0.78 | MAOA (1.00) | CCNB2CDK1CCNB1CCNA2CDK2 | |
| Hydrochloric Acid SCHEMBL970432 | 0.78 | CCNB2 (0.64) | CCNB2CDK1CCNB1CCNA2CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7348336-B2 | Substituted β-carbolines | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2008-03-25 | — | — | US | disclosed |
| US-20060166978-A1 | Substituted beta carbolines | SANOFI-AVENTIS DEUTSCHLAND GMBH | 2006-07-27 | — | — | US | disclosed |
| US-7026331-B2 | Substituted beta-carbolines | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2006-04-11 | — | — | US | disclosed |
| US-20040110759-A1 | Substituted beta carbolines | AVENTIS PHARMA DEUTSCHLAND GMBH | 2004-06-10 | — | — | US | disclosed |
| US-6627637-B2 | I kappa B kinase inhibitors for treating various disorders including arthritis | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2003-09-30 | — | — | US | disclosed |
| US-20020099068-A1 | Substituted beta carbolines | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2002-07-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040110759-A1 | Substituted beta carbolines | CSNK1A1, CSNK2A1, CSNK2B | CCNB2 362/4885CDK1 86/4885CCNB1 275/4885 |
| US-20020099068-A1 | Substituted beta carbolines | CSNK1A1, CSNK2A1, CSNK2B | CCNB2 362/4885CDK1 86/4885CCNB1 275/4885 |
| US-20060166978-A1 | Substituted beta carbolines | NFKBIA, RELA, IKBKG | CCNB2 865/4885CDK1 365/4885CCNB1 716/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.