Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 2/20 | 0.49 |
| ▸ | VCP | P55072 | 2/20 | 0.43 |
| ▸ | ACHE | P22303 | 4/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | SYK | P43405 | 3/20 | 0.38 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | PTGIR | P43119 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.37 |
| ▸ | USP7 | Q93009 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.36 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.36 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4824684 | 0.74 | TLR8 (0.43) | ALDH1A1KDM4ETDP1 | |
| SCHEMBL4823172 | 0.73 | ADORA1 (0.51) | CNR1ALDH1A1MAPTRAB9A | |
| SCHEMBL12327196 | 0.65 | GLA (0.43) | ALDH1A1MAPTRAB9A | |
| SCHEMBL22002181 | 0.64 | KDM4E (0.45) | VCPALDH1A1LRRK2KDM4ERAB9A | |
| SCHEMBL11935225 | 0.62 | MAPT (0.45) | VCPACHEALDH1A1KDM1AKDM4E | |
| SCHEMBL13438905 | 0.62 | MAPT (0.45) | VCPACHEALDH1A1KDM1AKDM4E | |
| SCHEMBL1108661 | 0.62 | CRHR1 (0.51) | CNR1ALDH1A1SYKLRRK2KDM4E | |
| SCHEMBL1753116 | 0.62 | ACHE (0.58) | CNR1VCPACHEHIF1AKDM4E | |
| SCHEMBL4821659 | 0.62 | L3MBTL1 (0.53) | CNR1ALDH1A1KDM1AKDM4EPOLB | |
| SCHEMBL22969696 | 0.61 | TDP1 (0.58) | CNR1ACHEALDH1A1KDM4EPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7326706-B2 | Pyrazine modulators of cannabinoid receptors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-02-05 | — | — | US | disclosed |
| US-7326706-B2 | Pyrazine modulators of cannabinoid receptors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-02-05 | — | — | US | disclosed |
| US-7326706-B2 | Pyrazine modulators of cannabinoid receptors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-02-05 | — | — | US | disclosed |
| US-20050054659-A1 | Pyrazine modulators of cannabinoid receptors | BRISTOL-MYERS SQUIBB COMPANY | 2005-03-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050054659-A1 | Pyrazine modulators of cannabinoid receptors | CNR1, CNR2, GPR18 | CNR1 1/4885VCP 2429/4885ACHE 2287/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.