Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | PDE4A | P27815 | 8/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 8/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 8/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 8/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | PPARD | Q03181 | 1/20 | 0.40 |
| ▸ | PPARA | Q07869 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4818551 | 0.85 | PPARG (0.51) | ALDH1A1SMN1; SMN2L3MBTL1ACHEPDE4A | |
| SCHEMBL30504079 | 0.84 | TUBB4A (0.46) | ALDH1A1SMN1; SMN2DRD2ACHEHPGD | |
| SCHEMBL30504081 | 0.84 | TUBB4A (0.46) | ALDH1A1SMN1; SMN2DRD2ACHEHPGD | |
| SCHEMBL4821120 | 0.83 | ACHE (0.40) | SMN1; SMN2L3MBTL1DRD2ACHEPDE4A | |
| SCHEMBL5635730 | 0.81 | PPARG (0.42) | L3MBTL1DRD2ACHEHPGDPPARG | |
| SCHEMBL4824733 | 0.80 | MAPK1 (0.53) | ALDH1A1SMN1; SMN2DRD2ACHEHPGD | |
| SCHEMBL15004196 | 0.79 | DRD2 (0.47) | SMN1; SMN2L3MBTL1DRD2ACHEPDE4A | |
| SCHEMBL10702236 | 0.78 | PDE4A (0.53) | ALDH1A1SMN1; SMN2L3MBTL1PDE4APDE4B | |
| SCHEMBL4827029 | 0.78 | PDE4A (0.50) | ALDH1A1SMN1; SMN2L3MBTL1ACHEPDE4A | |
| SCHEMBL4823200 | 0.78 | DRD2 (0.40) | SMN1; SMN2L3MBTL1DRD2ACHEPDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7470723-B2 | Diphenylethylene compounds and uses thereof | CELGENE CORPORATION (US) | 2008-12-30 | — | — | US | disclosed |
| EP-1799634-A2 | DIPHENYLETHYLENE COMPOUNDS AND USES THEREOF | CELGENE CORPORATION (US) | 2007-06-27 | — | — | EP | disclosed |
| WO-2006026747-A2 | DIPHENYLETHYLENE COMPOUNDS AND USES THEREOF | CELGENE CORPORATION (US) | 2006-03-09 | — | — | WO | disclosed |
| US-20050107339-A1 | Diphenylethylene compounds and uses thereof | CELGENE CORPORATION | 2005-05-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050107339-A1 | Diphenylethylene compounds and uses thereof | VHL, TNF, PTGES | ALDH1A1 124/4885SMN1; SMN2 2969/4885L3MBTL1 2413/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.