Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRD5A2 | P31213 | 1/20 | 0.82 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.74 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.74 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.62 |
| ▸ | MEN1 | O00255 | 2/20 | 0.62 |
| ▸ | NPC1 | O15118 | 4/20 | 0.61 |
| ▸ | RAB9A | P51151 | 4/20 | 0.61 |
| ▸ | HPGD | P15428 | 4/20 | 0.61 |
| ▸ | MAPT | P10636 | 2/20 | 0.61 |
| ▸ | PKM | P14618 | 2/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.61 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.61 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.61 |
| ▸ | RELA | Q04206 | 1/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.59 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7475049 | 0.91 | SRD5A2 (0.75) | SRD5A2ALDH1A1MAPK1KMT2AMEN1 | |
| SCHEMBL7816239 | 0.91 | SRD5A2 (0.81) | SRD5A2ALDH1A1MAPK1NPC1RAB9A | |
| SCHEMBL18546949 | 0.89 | SRD5A2 (0.73) | SRD5A2ALDH1A1MAPK1KMT2AMEN1 | |
| SCHEMBL4824992 | 0.87 | NPSR1 (0.74) | SRD5A2MAPK1NPC1RAB9AHPGD | |
| SCHEMBL2601929 | 0.87 | ALDH1A1 (0.74) | SRD5A2ALDH1A1MAPK1KMT2AMEN1 | |
| SCHEMBL10534958 | 0.86 | SRD5A2 (0.64) | SRD5A2ALDH1A1MAPK1KMT2AMEN1 | |
| Piperonylic Acid SCHEMBL142318 | 0.85 | ALDH1A1 (1.00) | SRD5A2ALDH1A1MAPK1KMT2AMEN1 | |
| Piperonylic Acid SCHEMBL3946119 | 0.85 | ALDH1A1 (1.00) | SRD5A2ALDH1A1MAPK1KMT2AMEN1 | |
| Piperonylic Acid SCHEMBL31119409 | 0.85 | ALDH1A1 (1.00) | SRD5A2ALDH1A1MAPK1KMT2AMEN1 | |
| SCHEMBL408967 | 0.85 | ALDH1A1 (0.71) | SRD5A2ALDH1A1MAPK1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100482651-C | Diaminothiazoles | HOFFMANN LA ROCHE (CH) | 2009-04-29 | — | — | CN | claimed |
| CN-1487927-A | Diaminothiazoles | - | 2004-04-07 | — | — | CN | claimed |
| CN-104910029-B | 4-amino-3-acyl group-beta naphthal compounds and its production and use | 苏州大学 | 2016-08-31 | — | — | CN | disclosed |
| CN-104910029-A | 4-amino-3-acyl-2-naphthol compound as well as preparation method and purpose thereof | UNIV SOOCHOW | 2015-09-16 | — | — | CN | disclosed |
| CN-1393446-B | Fused pyrazole compound | YUNG SHIN PHARM IND CO LTD | 2010-06-16 | — | — | CN | disclosed |
| CN-100482651-C | Diaminothiazoles | HOFFMANN LA ROCHE (CH) | 2009-04-29 | — | — | CN | disclosed |
| US-7470723-B2 | Diphenylethylene compounds and uses thereof | CELGENE CORPORATION (US) | 2008-12-30 | — | — | US | disclosed |
| US-20080114061-A1 | Diphenylethylene compounds and uses thereof | CELGENE CORPORATION | 2008-05-15 | — | — | US | disclosed |
| US-7312241-B2 | Diphenylethylene compounds and uses thereof | CELGENE CORPORATION (US) | 2007-12-25 | — | — | US | disclosed |
| EP-1799634-A2 | DIPHENYLETHYLENE COMPOUNDS AND USES THEREOF | CELGENE CORPORATION (US) | 2007-06-27 | — | — | EP | disclosed |
| EP-1603864-A4 | DIPHENYLETHYLENE COMPOUNDS AND USES THEREOF | CELGENE CORP (US) | 2007-04-11 | — | — | EP | disclosed |
| WO-2006026747-A2 | DIPHENYLETHYLENE COMPOUNDS AND USES THEREOF | CELGENE CORPORATION (US) | 2006-03-09 | — | — | WO | disclosed |
| EP-1603864-A2 | DIPHENYLETHYLENE COMPOUNDS AND USES THEREOF | CELGENE CORPORATION (US) | 2005-12-14 | — | — | EP | disclosed |
| US-20050107339-A1 | Diphenylethylene compounds and uses thereof | CELGENE CORPORATION | 2005-05-19 | — | — | US | disclosed |
| US-20050014727-A1 | Diphenylethylene compounds and uses thereof | CELGENE CORPORATION | 2005-01-20 | — | — | US | disclosed |
| WO-2004078144-A2 | DIPHENYLETHYLENE COMPOUNDS AND USES THEREOF | CELGENE CORPORATION (US) | 2004-09-16 | — | — | WO | disclosed |
| CN-1487927-A | Diaminothiazoles | - | 2004-04-07 | — | — | CN | disclosed |
| CN-1393446-A | Fused pyrazole compound | YONGXIN PHARMACEUTICAL CO LTD (CN) | 2003-01-29 | — | — | CN | disclosed |
| US-6465472-B1 | SUCH AS 1-(2-DIETHYLAMINOETHYL)-6,7-METHYLENEDIOXY-4-(3,4-METHYLENE -DIOXYPHENYL)QUINAZOLIN-2(1H)-ONE; AMPA IONOTROPIC RECEPTOR ANTAGONISTS; ANTICONVULSANTS, COGNITIVE ENHANCERS, PREVENTION OF NEURODEGENERATION | EURO-CELTIQUE S.A. (LU) | 2002-10-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050107339-A1 | Diphenylethylene compounds and uses thereof | VHL, TNF, PTGES | SRD5A2 270/4885ALDH1A1 124/4885MAPK1 3043/4885 |
| US-20080114061-A1 | Diphenylethylene compounds and uses thereof | VHL, TNF, PTGES | SRD5A2 270/4885ALDH1A1 124/4885MAPK1 3043/4885 |
| US-20050014727-A1 | Diphenylethylene compounds and uses thereof | VHL, TNF, PTGES | SRD5A2 270/4885ALDH1A1 124/4885MAPK1 3043/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.