SCHEMBL7475049

SCHEMBL7475049

O=C(c1ccc(O)cc1)c1ccc2c(c1)OCO2

nearest known ligand 0.75

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SRD5A2 P31213 1/20 0.75
ALDH1A1 P00352 4/20 0.62
MAPK1 P28482 1/20 0.62
CYP3A4 P08684 2/20 0.60
MAPT P10636 4/20 0.57
NPC1 O15118 3/20 0.57
RAB9A P51151 3/20 0.57
P2RX5 Q93086 1/20 0.56
P2RX4 Q99571 1/20 0.56
P2RX7 Q99572 1/20 0.56
P2RX2 Q9UBL9 1/20 0.56
NPSR1 Q6W5P4 1/20 0.55
MEN1 O00255 1/20 0.54
KMT2A Q03164 1/20 0.54
HPGD P15428 3/20 0.54
PKM P14618 2/20 0.54
ESR1 P03372 1/20 0.54
ESR2 Q92731 1/20 0.54
LMNA P02545 1/20 0.54
HTT P42858 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4824941 0.91 SRD5A2 (0.82) SRD5A2ALDH1A1MAPK1CYP3A4MAPT
SCHEMBL7816239 0.86 SRD5A2 (0.81) SRD5A2ALDH1A1MAPK1MAPTNPC1
SCHEMBL18546949 0.84 SRD5A2 (0.73) SRD5A2ALDH1A1MAPK1MAPTNPC1
SCHEMBL4823544 0.80 RAB9A (0.68) SRD5A2ALDH1A1MAPK1MAPTNPC1
SCHEMBL11466287 0.80 SRD5A2 (0.67) SRD5A2ALDH1A1MAPK1CYP3A4MAPT
SCHEMBL2601929 0.79 ALDH1A1 (0.74) SRD5A2ALDH1A1MAPK1CYP3A4MAPT
SCHEMBL4824992 0.79 NPSR1 (0.74) SRD5A2MAPK1MAPTNPC1RAB9A
SCHEMBL10534958 0.78 SRD5A2 (0.64) SRD5A2ALDH1A1MAPK1CYP3A4MAPT
Piperonylic Acid SCHEMBL142318 0.77 ALDH1A1 (1.00) SRD5A2ALDH1A1MAPK1CYP3A4MAPT
Piperonylic Acid SCHEMBL31119409 0.77 ALDH1A1 (1.00) SRD5A2ALDH1A1MAPK1CYP3A4MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0860433-B1 QUINOLINE DERIVATIVES AND QUINAZOLINE DERIVATIVES INHIBITING AUTOPHOSPHORYLATION OF GROWTH FACTOR RECEPTOR ORIGINATING IN PLATELET AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME KIRIN BREWERY (JP) 2002-07-03 EP disclosed
US-6143764-A ETHER DERIVATIVES OF QUINOLINE, ANTITUMOR AGENTS KIRIN BEER KABUSHIKI KAISHA (JP) 2000-11-07 US disclosed
EP-0860433-A1 QUINOLINE DERIVATIVES AND QUINAZOLINE DERIVATIVES INHIBITING AUTOPHOSPHORYLATION OF GROWTH FACTOR RECEPTOR ORIGINATING IN PLATELET AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME KIRIN BEER KABUSHIKI KAISHA (JP) 1998-08-26 EP disclosed