Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.54 |
| ▸ | MEN1 | O00255 | 4/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | NPY1R | P25929 | 1/20 | 0.54 |
| ▸ | NPY2R | P49146 | 1/20 | 0.54 |
| ▸ | CA12 | O43570 | 2/20 | 0.51 |
| ▸ | CA9 | Q16790 | 2/20 | 0.51 |
| ▸ | HTR2A | P28223 | 1/20 | 0.50 |
| ▸ | HTR6 | P50406 | 1/20 | 0.50 |
| ▸ | CTSV | O60911 | 2/20 | 0.49 |
| ▸ | CTSL | P07711 | 2/20 | 0.49 |
| ▸ | PARP1 | P09874 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | GFER | P55789 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4959623 | 0.92 | CTSV (0.55) | MAPTMEN1KMT2AALDH1A1LMNA | |
| SCHEMBL23885352 | 0.84 | PLA2G1B (0.51) | MAPTMEN1KMT2AALDH1A1LMNA | |
| SCHEMBL4011471 | 0.81 | ALDH1A1 (0.68) | MAPTMEN1KMT2AALDH1A1LMNA | |
| SCHEMBL30312308 | 0.81 | ALDH1A1 (0.68) | MAPTMEN1KMT2AALDH1A1LMNA | |
| SCHEMBL8899073 | 0.80 | KIF11 (0.53) | MAPTMEN1KMT2AALDH1A1LMNA | |
| SCHEMBL26630415 | 0.78 | MAPT (0.56) | MAPTMEN1KMT2AALDH1A1LMNA | |
| SCHEMBL3242431 | 0.77 | MEN1 (0.49) | MAPTMEN1KMT2AALDH1A1LMNA | |
| SCHEMBL30554621 | 0.77 | MEN1 (0.49) | MAPTMEN1KMT2AALDH1A1LMNA | |
| SCHEMBL13949744 | 0.76 | MEN1 (0.51) | MAPTMEN1KMT2AALDH1A1LMNA | |
| SCHEMBL29540314 | 0.76 | GABRA1 (0.70) | MAPTMEN1KMT2AALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7465738-B2 | Compounds useful as promoters of SMN2 | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-12-16 | — | — | US | disclosed |
| US-20050065173-A1 | Compounds useful as promoters of SMN2 | VERTEX PHARMACEUTICALS INCORPORATED | 2005-03-24 | — | — | US | disclosed |
| WO-2004113305-A2 | DIAMINO SUBSTITUTED QUINAZOLINE DERIVATIVES AS PROMOTERS OF SMN2 | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2004-12-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050065173-A1 | Compounds useful as promoters of SMN2 | SMN1; SMN2, NSUN2, MECP2 | MAPT 1001/4885MEN1 3565/4885KMT2A 410/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.