⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4945264 | 0.81 | — | — | |
| SCHEMBL16656334 | 0.79 | — | — | |
| SCHEMBL5059682 | 0.79 | ALDH1A1 (0.37) | — | |
| SCHEMBL55353 | 0.79 | ALDH1A1 (0.37) | — | |
| SCHEMBL23384087 | 0.75 | — | — | |
| SCHEMBL9113963 | 0.75 | — | — | |
| SCHEMBL106466 | 0.75 | — | — | |
| SCHEMBL3863161 | 0.75 | — | — | |
| SCHEMBL19418536 | 0.75 | — | — | |
| SCHEMBL9436380 | 0.75 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0398391-A1 | 0,0'-Dicyanoethyl-phosphoramidites, a process for their preparation and their use in phosphorylation reactions | CHIRON CORPORATION (US) | 1990-11-22 | — | — | EP | claimed |
| US-20210147466-A1 | IMPROVED PROCESSES FOR THE PREPARATION OF GUADECITABINE AND INTERMEDIATES THEREOF | TEVA CZECH INDUSTRIES S.R.O. (CZ) | 2021-05-20 | — | — | US | disclosed |
| EP-3137478-A2 | PHOSPHOROUS PROTECTING GROUPS AND METHODS OF PREPARATION AND USE THEREOF | Agilent Technologies, Inc. (US) | 2017-03-08 | — | — | EP | disclosed |
| WO-2015168461-A2 | PHOSPHOROUS PROTECTING GROUPS AND METHODS OF PREPARATION AND USE THEREOF | AGILENT TECHNOLOGIES, INC. (US) | 2015-11-05 | — | — | WO | disclosed |
| US-9090648-B2 | Cationic oligonucleotides, automated methods for preparing same and their uses | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 2015-07-28 | — | — | US | disclosed |
| WO-2013142525-A1 | SUBSTITUTED NUCLEOSIDES, NUCLEOTIDES AND ANALOGS THEREOF | ALIOS BIOPHARMA, INC. (US) | 2013-09-26 | — | — | WO | disclosed |
| US-7427675-B2 | Compounds and methods for the characterization of oligonucleotides | ISIS PHARMACEUTICALS, INC. (US) | 2008-09-23 | — | — | US | disclosed |
| US-20080207551-A1 | MODIFIED OLIGONUCLEOTIDES CONTAINING DIPHOSPHODIESTER INTERNUCLEOTIDE LINKAGES | BOARD OF GOVERNORS FOR HIGHER EDUCATION, STATE OF RHODE ISLAND AND PROVIDENCE (US) | 2008-08-28 | — | — | US | disclosed |
| WO-2006023880-A2 | COMPOUNDS AND METHODS FOR THE CHARACTERIZATION OF OLIGONUCLEOTIDES | ISIS PHARMACEUTICALS, INC. (US) | 2006-03-02 | — | — | WO | disclosed |
| US-20060040308-A1 | Compounds and methods for the characterization of oligonucleotides | ISIS PHARMACEUTICALS, INC. (US) | 2006-02-23 | — | — | US | disclosed |
| US-RE34069-E | PROCESS FOR THE PREPARATION OF OLIGONUCLEOTIDES | BIOSYNTECH GMBH (DE) | 1992-09-15 | — | — | US | disclosed |
| US-4725677-A | USING PHOSPHINE DERIVATIVE | BIOSYNTECH GMBH (DE) | 1988-02-16 | — | — | US | disclosed |