Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA3 | P32297 | 9/20 | 0.46 |
| ▸ | CHRNB4 | P30926 | 8/20 | 0.46 |
| ▸ | CHRNB2 | P17787 | 8/20 | 0.46 |
| ▸ | CHRNA4 | P43681 | 7/20 | 0.46 |
| ▸ | CHRNA1 | P02708 | 3/20 | 0.46 |
| ▸ | CHRNG | P07510 | 1/20 | 0.46 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.46 |
| ▸ | CHRND | Q07001 | 1/20 | 0.46 |
| ▸ | CHRNA2 | Q15822 | 1/20 | 0.46 |
| ▸ | PIM1 | P11309 | 4/20 | 0.40 |
| ▸ | PRKCB | P05771 | 1/20 | 0.39 |
| ▸ | PRKCA | P17252 | 1/20 | 0.39 |
| ▸ | PRKCH | P24723 | 1/20 | 0.39 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.39 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.39 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.39 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.39 |
| ▸ | DPP4 | P27487 | 2/20 | 0.37 |
| ▸ | CLK2 | P49760 | 1/20 | 0.36 |
| ▸ | CLK3 | P49761 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4827864 | 1.00 | CHRNA3 (0.46) | CHRNA3CHRNB4CHRNB2CHRNA4CHRNA1 | |
| SCHEMBL4828838 | 0.86 | CHRNB2 (0.56) | CHRNA3CHRNB4CHRNB2CHRNA4PIM1 | |
| SCHEMBL4827538 | 0.86 | CHRNB2 (0.56) | CHRNA3CHRNB4CHRNB2CHRNA4PIM1 | |
| SCHEMBL4828087 | 0.81 | HRH4 (0.48) | CHRNA3CHRNB4CHRNB2CHRNA4CHRNA1 | |
| SCHEMBL4830391 | 0.81 | HRH4 (0.48) | CHRNA3CHRNB4CHRNB2CHRNA4CHRNA1 | |
| SCHEMBL29108020 | 0.80 | CHRNB2 (0.47) | CHRNA3CHRNB4CHRNB2CHRNA4CHRNA1 | |
| SCHEMBL30665749 | 0.80 | CHRNB2 (0.47) | CHRNA3CHRNB4CHRNB2CHRNA4CHRNA1 | |
| SCHEMBL29108032 | 0.80 | CHRNB2 (0.47) | CHRNA3CHRNB4CHRNB2CHRNA4CHRNA1 | |
| SCHEMBL30665748 | 0.80 | CHRNB2 (0.47) | CHRNA3CHRNB4CHRNB2CHRNA4CHRNA1 | |
| SCHEMBL29043100 | 0.79 | CHRNB2 (0.46) | CHRNA3CHRNB4CHRNB2CHRNA4CHRNA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7332504-B2 | Heterocyclic substituted aminoazacycles useful as central nervous system agents | ABBOTT LABORATORIES (US) | 2008-02-19 | — | — | US | claimed |
| US-7332504-B2 | Heterocyclic substituted aminoazacycles useful as central nervous system agents | ABBOTT LABORATORIES (US) | 2008-02-19 | — | — | US | disclosed |